ArticleScientific reports2019
High information capacity DNA-based data storage with augmented encoding characters using degenerate bases.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Comparison of state-of-the-art error-correction coding for sequence-based DNA data storage.Nature communications · 2026Article
- Error characterization and error correction approaches in combinatorial DNA-based storage.Scientific reports · 2026Article
- Quantitative Assessment of Randomized DNA Base Sequences Using Multi-Model Physical Analysis for High-Fidelity Data Storage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- DNA diamond formulates a decomposable composite letter constellation model for DNA data storage.Nature communications · 2026Article
- Dna-storalator: a computational simulator for DNA data storage.BMC bioinformatics · 2025Article
- DNA storage: The future direction for medical cold data storage.Synthetic and systems biotechnology · 2025Review
- Coli bond: A dual-function encryption system for secure information storage and transmission by microorganisms.PloS one · 2025Article
- Nanopore decoding with speed and versatility for data storage.Bioinformatics (Oxford, England) · 2024Article
- Recent progress in DNA data storage based on high-throughput DNA synthesis.Biomedical engineering letters · 2024Review
- Genomic and molecular characterization of a cyprinid herpesvirus 2 YC-01 strain isolated from gibel carp.Heliyon · 2024Article
- Efficient DNA-based data storage using shortmer combinatorial encoding.Scientific reports · 2024Article
- A dual-rule encoding DNA storage system using chaotic mapping to control GC content.Bioinformatics (Oxford, England) · 2024Article
- DNA as a universal chemical substrate for computing and data storage.Nature reviews. Chemistry · 2024Review
- Highly Accurate Sequence- and Position-Independent Error Profiling of DNA Synthesis and Sequencing.ACS synthetic biology · 2023Article
- FrameD: framework for DNA-based data storage design, verification, and validation.Bioinformatics (Oxford, England) · 2023Article
- Scaling logical density of DNA storage with enzymatically-ligated composite motifs.Scientific reports · 2023Article
- Reducing cost in DNA-based data storage by sequence analysis-aided soft information decoding of variable-length reads.Bioinformatics (Oxford, England) · 2023Article
- An outlook on the current challenges and opportunities in DNA data storage.Biotechnology advances · 2023Review
- DNA Data Storage.Biotech (Basel (Switzerland)) · 2023Review
- Study on DNA Storage Encoding Based IAOA under Innovation Constraints.Current issues in molecular biology · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose the use of degenerate bases as encoding characters in addition to A, C, G, and T, which augments the amount of data that can be stored per length of DNA sequence designed (information capacity) and lowering the amount of DNA synthesis per storing unit data. Using the proposed method, we experimentally achieved an information capacity of 3.37 bits/character. The demonstrated information capacity is more than twice when compared to the highest information capacity previously achieved. The proposed method can be integrated with synthetic technologies in the future to reduce the cost of DNA-based data storage by 50%.
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