Evidence map›Paper›PMID 31036890›Full record

ReviewNature biomedical engineering2019

A roadmap for the clinical implementation of optical-imaging biomarkers.

Dale J Waterhouse, Catherine R M Fitzpatrick, Brian W Pogue, James P B O'Connor, Sarah E Bohndiek

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  6. Biomaterials for biomarker imaging and detection.Journal of advanced research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dale J WaterhouseDepartment of Physics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-5530-6857
Catherine R M FitzpatrickCancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK.
Brian W PogueThayer School of Engineering, Dartmouth, NH, USA.
James P B O'ConnorDivision of Cancer Sciences, University of Manchester, Manchester, UK.
Sarah E BohndiekDepartment of Physics, University of Cambridge, Cambridge, UK. seb53@cam.ac.uk.ORCID http://orcid.org/0000-0003-0371-8635

Funding

Cancer Research UK 15267Cancer Research UK 16267Cancer Research UK 16465Cancer Research UK 21102Cancer Research UK 21142Cancer Research UK 22746Cancer Research UK 24669Cancer Research UK 26851Cancer Research UK 28683Cancer Research UK C14303/A17197Cancer Research UK C47594/A16267Cancer Research UK C47594/A21102Cancer Research UK C55962/A24669
6 · The paper itself

Abstract

Clinical workflows for the non-invasive detection and characterization of disease states could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities and challenges towards the clinical implementation of optical-imaging biomarkers for the early detection of cancer by analysing two case studies: the assessment of skin lesions in primary care, and the surveillance of patients with Barrett's oesophagus in specialist care. We stress the importance of technical and biological validations and clinical-utility assessments, and the need to address implementation bottlenecks. In addition, we define a translational roadmap for the widespread clinical implementation of optical-imaging technologies.

Indexed as

Optical ImagingAnimalsBiomarkersEarly Detection of CancerHumansMelanomaPrimary Health CareTranslational Research, BiomedicalBiomarkers

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.