ArticleScientific reports2019
Amino acid derangements in adults with severe falciparum malaria.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Malaria and cancer: common features and interactions.Trends in parasitology · 2026Review
- Temporal multi-tissue profiling reveals metabolites linked to immune response and malaria parasitemia control.iScience · 2026Article
- Application of a Non-Targeted Metabolomics Study inInternational journal of molecular sciences · 2025Article
- Systems Biological Analysis of Immune-Metabolic Host Responses to Distinct Malaria Parasites.ACS omega · 2025Article
- In vitro cultured malaria hypnozoites leave a footprint of specific metabolites.PLoS pathogens · 2025Article
- Malaria-induced dysregulation of selected micronutrients (Ca, Mg, Na, K, Zn, Fe, Co) and plasma free amino acids; implications for pathogenesis and host immunity in a Nigerian population.Parasite epidemiology and control · 2025Article
- β-hydroxybutyrate inhibits Plasmodium falciparum development and confers protection against malaria in mice.Nature metabolism · 2025Article
- A shared inflammatory signature across severe malaria syndromes manifested by transcriptomic, proteomic and metabolomic analyses.Nature communications · 2025Article
- tRNA regulation and amino acid usage bias reflect a coordinated metabolic adaptation iniScience · 2024Article
- Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis.PLoS pathogens · 2024Article
- Longitudinal associations of plasma amino acid levels with recovery from malarial coma.Malaria journal · 2024Observational
- RNA polymerase III is involved in regulatingeLife · 2024Article
- Amino acid supplementation confers protection to red blood cells before Plasmodium falciparum bystander stress.Blood advances · 2024Article
- Longitudinal associations of plasma amino acid levels with recovery from malarial coma.Research square · 2024Article
- Host metabolomic responses in recurrent P. vivax malaria.Scientific reports · 2024Article
- The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024Review
- Starvation induces changes in abundance and small RNA cargo of extracellular vesicles released from Plasmodium falciparum infected red blood cells.Scientific reports · 2023Article
- Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis.Frontiers in human neuroscience · 2023Article
- Diagnosis of cerebral malaria: Tools to reduceFrontiers in cellular and infection microbiology · 2023Review
- Plasma Amino Acid Concentrations in Children With Severe Malaria Are Associated With Mortality and Worse Long-term Kidney and Cognitive Outcomes.The Journal of infectious diseases · 2022Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
Abstract
Amino acid derangements are common in severe falciparum malaria and have been associated with endothelial dysfunction (L-arginine), metabolic acidosis (alanine and lactate), and disease severity (phenylalanine and tryptophan metabolites). Whether these amino acid perturbations reflect isolated pathogenic mechanisms or if they are part of overall changes in amino acid metabolism is unclear. To investigate this, we prospectively simultaneously quantified a broad range of plasma free amino acids (PFAA) using HPLC-MRM-Mass spectrometry in relation to presenting symptoms in adults with severe malaria (n = 88), septicaemia (n = 88), uncomplicated malaria (n = 71), and healthy controls (n = 48) from Bangladesh. The total plasma concentration of measured amino acids was significantly reduced in each of the patient groups when compared to normal levels observed in healthy local controls: uncomplicated malaria -54%, severe malaria -23%, and sepsis -32%, (p = <0.001). Inspection of amino acid profiles revealed that in each group the majority of amino acids were below normal levels, except for phenylalanine. Among patients with severe malaria, L-lactate was strongly associated with an increase of the total amino acid concentration, likely because this reflects tissue hypoxia. Our data confirm previously described amino acid abnormalities, likely resulting from overall changes in the concentration of PFAA.
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