Observational studyScientific reports2019
The usefulness of C-reactive protein and procalcitonin to predict prognosis in septic shock patients: A multicenter prospective registry-based observational study.
Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic value of C-reactive protein levels in pulmonary infections: A systematic review and meta-analysis.Medicine · 2025Pooled it
- C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis.Therapeutic advances in respiratory diseasePooled it
- Development and temporal validation of SCRAPS scoring tool to predict poor prognosis in gram negative sepsis patients requiring early intensive care or high dependency unit admission.BMC infectious diseases · 2026Observational
- Early Peri-Admission Lactate-to-Albumin (LAR), C-Reactive Protein-to-Albumin (CAR), and Procalcitonin-to-Albumin (PAR) Ratios and ICU Mortality in a Tertiary Cardiac ICU.Journal of clinical medicine · 2026Article
- Human beta defensins 3 and 6 serve as diagnostic tools for identifying sepsis and pneumonia.Frontiers in immunology · 2026Article
- A Novel Composite Bioscore Integrating Biomarkers, Clinical Scores, and Comorbidity Indices for Prognostic Stratification in Sepsis.Journal of inflammation research · 2026Article
- Persistent Severe Acute Kidney Injury Among Critically Ill Patients: Outcomes and Predictive Markers-A Single-Center Retrospective Cohort Study.Critical care research and practice · 2026Article
- Neutrophil-derived ROS as a rapid functional biomarker: diagnostic and prognostic performance of the Leukocyte ImmunoTest in infection and sepsis.Frontiers in immunology · 2026Observational
- Ceftazidime-Avibactam: A Retrospective Analysis of Multicenter Real-World Data and Factors Affecting Mortality.Infectious diseases & clinical microbiology · 2025Article
- Is GDF15 a Feasible Biomarker in Sepsis?Diagnostics (Basel, Switzerland) · 2025Article
- Blood from septic patients with necrotising soft tissue infection treated with hyperbaric oxygen reveal different gene expression patterns compared to standard treatment.BMC medical genomics · 2025Observational
- A Mortality Risk Prediction Model for Septic Shock in Patients Aged ≥50: Role of Norepinephrine Index and Procalcitonin.International journal of general medicine · 2025Article
- Association between serum procalcitonin levels and outcomes of patients admitted to two tertiary paediatric intensive care units in Bloemfontein: A retrospective analytical study.The Southern African journal of critical care : the official journal of the Critical Care Society · 2025Article
- C-reactive protein and procalcitonin during course of sepsis and septic shock.Irish journal of medical science · 2024Article
- Kinetics of C-reactive protein during extracorporeal membrane oxygenation.The International journal of artificial organs · 2024Observational
- The value of lymphocyte-to-C-reactive protein ratio for predicting clinical outcomes in patients with sepsis in intensive care unit: a retrospective single-center study.Frontiers in molecular biosciences · 2024Article
- Use of inflammatory markers as predictor for mechanical ventilation in COVID-19 patients with stages IIIb-V chronic kidney disease?World journal of virology · 2023Article
- Article
- Basal procalcitonin, C-reactive protein, interleukin-6, and presepsin for prediction of mortality in critically ill septic patients: a systematic review and meta-analysis.Diagnostic and prognostic research · 2023Review
- Hyperglycemia in COVID-19 infection without diabetes mellitus: Association with inflammatory markers.World journal of clinical cases · 2023Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to evaluate the prognostic value of C-reactive protein (CRP), procalcitonin (PCT), and their combination for mortality in patients with septic shock. This multicenter, prospective, observational study was conducted between November 2015 and December 2017. A total of 1,772 septic shock patients were included, and the overall 28-day mortality was 20.7%. Although both CRP and PCT were elevated in the non-survivor group, only CRP had statistical significance (11.9 mg/dL vs. 14.7 mg/dL, p = 0.003, 6.4 ng/mL vs. 8.2 ng/mL, p = 0.508). Multivariate analysis showed that CRP and PCT were not independent prognostic markers. In the subgroup analysis of the CRP and PCT combination matrix using their optimal cut-off values (CRP 14.0 mg/dL, PCT 17.0 ng/dL), both CRP and PCT elevated showed significantly higher mortality (Odds ratio 1.552 [95% Confidence intervals 1.184-2.035]) than both CRP and PCT not elevated (p = 0.001) and only PCT elevated (p = 0.007). However, both CRP and PCT elevated was also not an independent predictor in multivariate analysis. Initial levels of CRP and PCT alone and their combinations in septic shock patients had a limitation to predict 28-day mortality. Future research is needed to determine new biomarkers for early prognostication in patients with septic shock.
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