ArticleNature communications2019
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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0cells of the map it votes in
65citing papers in PubMed
7.7field-weighted citation impact, top 1% of its field
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Who cites it
65 citing papers in PubMed, 91 citations in OpenAlex.
- Mechanistic insights into Orai dynamics during pore opening.Channels (Austin, Tex.) · 2026Review
- A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription.bioRxiv : the preprint server for biology · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Latrophilin-1-Mediated GCells · 2026Article
- Differential Sensitivity of TRPC- and ORAI-Mediated Calcium Entries to 1‑[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole Chloride (SKF-96365).ACS pharmacology & translational science · 2025Article
- Secretin targets interstitial cells of Cajal to regulate intestinal contractions.EMBO reports · 2025Article
- Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025Review
- A subset of Orai1α and Orai1β subunits heteromerizes to form CRAC channels.Cell communication and signaling : CCS · 2025Article
- Store-Operated Calcium Channels in the Nervous System.Annual review of physiology · 2025Review
- Ca2+ tunneling architecture and function are important for secretion.The Journal of cell biology · 2025Article
- Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins.Journal of cellular physiology · 2025Article
- Differential functional role of Orai1 variants in constitutive CaThe Journal of biological chemistry · 2024Article
- MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development.PLoS biology · 2024Article
- Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Orai1α and Orai1β support calcium entry and mammosphere formation in breast cancer stem cells.Scientific reports · 2023Article
- Article
- Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1.Nature communications · 2023Article
- Article
- A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.eLife · 2023Article
- Store-Operated Calcium Entry in Breast Cancer Cells Is Insensitive to Orai1 and STIM1 N-Linked Glycosylation.Cancers · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Xuexin ZhangDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA. xzhang3@pennstatehealth.psu.edu.
Trayambak PathakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
Ryan YoastDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
Scott EmrichDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
Ping XinDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
Robert M NwokonkoDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
Martin JohnsonDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
Shilan WuDepartment of Health and Human Services, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr, Research Triangle Park, Durham, NC, 27709, USA.
Céline DelierneuxDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
Maxime GueguinouDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
Nadine HempelDepartment of Pharmacology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.
James W PutneyDepartment of Health and Human Services, Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Dr, Research Triangle Park, Durham, NC, 27709, USA.
Donald L GillDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA.ORCID http://orcid.org/0000-0003-0587-2548
Mohamed TrebakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA, 17033, USA. mtrebak@psu.edu.
Pennsylvania State University · USNational Institutes of Health · US
Funding
Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7MCAPACITATIVE CALCIUM ENTRYZ01ES090087 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI PUTNEY, JAMES W · 1997 to 2008
$5.2MReceptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7MNRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4MUnderstanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9MCalcium Signaling Roles of STIM1 and STIM2 in Smooth MuscleR01GM109279 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2014 to 2017
$1.6MLeukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5MControl of Calcium Entry Signals in B CellsR01GM120783 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2016 to 2018
$1.3MGenes and miRNAs controlled by ORAI3 in cardiovascular remodelingR21AG050072 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEBECHE, DJAMEL, TREBAK, MOHAMED · 2016 to 2017
$471kIntramural NIH HHS Z01 ES090087NCATS NIH HHS TL1 TR002016NCATS NIH HHS UL1 TR002014NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NIA NIH HHS R21 AG050072NIGMS NIH HHS R01 GM109279NIGMS NIH HHS R01 GM120783NIGMS NIH HHS R35 GM131916
Abstract
ORAI1 constitutes the store-operated Ca
Indexed as
A Kinase Anchor ProteinsBlotting, WesternCalciumCyclic AMPCyclic AMP-Dependent Protein KinasesHEK293 CellsHumansNeoplasm ProteinsORAI1 ProteinPhosphorylationStromal Interaction Molecule 1Stromal Interaction Molecule 2AKAP5 protein, humanA Kinase Anchor ProteinsCalciumCyclic AMPCyclic AMP-Dependent Protein KinasesNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1Stromal Interaction Molecule 2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.