Evidence map›Paper›PMID 31036764›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Dynamic Network Activation of Hypothalamic MCH Neurons in REM Sleep and Exploratory Behavior.

Carlos Blanco-Centurion, SiWei Luo, Daniel J Spergel, Aurelio Vidal-Ortiz, Sorinel A Oprisan, Anthony N Van den Pol, Meng Liu, Priyattam J Shiromani

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. When dreams feel real: the MÖBIUS model.Communications biology · 2026
    Review
  5. Review
  6. Article
  7. Neuropeptidergic Input from the Lateral Hypothalamus to the Suprachiasmatic Nucleus Alters the Circadian Period in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  13. Article
  14. Article
  15. An EEG Signature of MCH Neuron Activities Predicts Cocaine Seeking.bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Searching for sleep in all the right places: My career in sleep research.Sleep advances : a journal of the Sleep Research Society · 2024
    Article
  20. Neural Control of REM Sleep and Motor Atonia: Current Perspectives.Current neurology and neuroscience reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Carlos Blanco-CenturionDepartments of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425.
SiWei LuoDepartments of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425.
Daniel J SpergelDepartment of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520.ORCID 0000-0002-5753-4332
Aurelio Vidal-OrtizLaboratory of Sleep Neuroscience, Ralph H. Johnson VA Medical Center, Charleston, South Carolina 29401, and.
Sorinel A OprisanDepartment of Physics and Astronomy, College of Charleston, Charleston, South Carolina 29424.ORCID 0000-0001-6585-3985
Anthony N Van den PolDepartment of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520.
Meng LiuDepartments of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, shiroman@musc.edu liumen@musc.edu.
Priyattam J ShiromaniDepartments of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, shiroman@musc.edu liumen@musc.edu.
Medical University of South Carolina · USYale University · USCollege of Charleston · USRalph H. Johnson VA Medical Center · US

Funding

Melanin Concentrating Hormone Neurons in SleepR01NS052287 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIROMANI, PRIYATTAM J. · 2006 to 2018
$3.4M
Gene Transfer for Cataplexy of NarcolepsyR01NS096151 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LIU, MENG · 2016 to 2020
$2.2M
Zona incerta GABA neurons modulate energy homeostasisR01DK115933 · NIDDK · YALE UNIVERSITY · PI GUNEL, MURAT · 2017 to 2021
$2.0M
Arcuate Nucleus Glutamatergic Neurons Modulate Energy HomeostasisR01DK084052 · NIDDK · YALE UNIVERSITY · PI VAN DEN POL, ANTHONY N · 2010 to 2013
$1.4M
Astroglia-Neuron Regulation of SleepR21NS098541 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIROMANI, PRIYATTAM J. · 2016 to 2017
$411k
Circuit Mapping for emotion-induced cataplexy of NarcolepsyR21NS101469 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LIU, MENG · 2017 to 2018
$406k
Selective Activation of Neurons to Control NarcolepsyR21NS079940 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIROMANI, PRIYATTAM J. · 2012 to 2013
$398k
BLR&D Research Career Scientist Award Application for Priyattam J. Shiromani, PhDIK6BX004216 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI SHIROMANI, PRIYATTAM J. · 2018 to 2025
–
Sleep Neurobiology and CircuitryI01BX000798 · VA · VA BOSTON HEALTH CARE SYSTEM · PI HOWARD C. BECKER · 2011 to 2026
–
BLRD VA I01 BX000798BLRD VA IK6 BX004216NIDDK NIH HHS R01 DK084052NIDDK NIH HHS R01 DK115933NINDS NIH HHS R01 NS052287NINDS NIH HHS R01 NS096151NINDS NIH HHS R21 NS079940NINDS NIH HHS R21 NS098541NINDS NIH HHS R21 NS101469
6 · The paper itself

Abstract

Most brain neurons are active in waking, but hypothalamic neurons that synthesize the neuropeptide melanin-concentrating hormone (MCH) are claimed to be active only during sleep, particularly rapid eye movement (REM) sleep. Here we use deep-brain imaging to identify changes in fluorescence of the genetically encoded calcium (Ca

Indexed as

AnimalsBrain MappingCalciumExploratory BehaviorFemaleHypothalamic HormonesHypothalamusMaleMelaninsMiceNeuronsOptical ImagingPituitary HormonesSleep, REMCalciumHypothalamic Hormonesmelanin-concentrating hormoneMelaninsPituitary Hormonescalcium imaginghypothalamusmelanin concentrating hormoneREM sleepsleep

Identifiers

PMID31036764
PMCPMC6670248
OpenAlexW2942865630

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.