ArticleBiology open2019
Numb regulates cell tension required for mammary duct elongation.
Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Application of a uniaxial force by pulling the skin around the mammary gland may affect the orientation of the ducts and the length of the mammary ductal network: Findings from computational modeling and laboratory experiments.PLoS computational biology · 2026Article
- Tumor suppressor FRMD3 controls mammary epithelial cell fate determination via notch signaling pathway.Science advances · 2024Article
- Review
- Transcriptome analysis to identify candidate genes related to mammary gland development of Bactrian camel (Frontiers in veterinary science · 2023Article
- Surface-tension-induced budding drives alveologenesis in human mammary gland organoids.Nature physics · 2021Article
- Revealing New Candidate Genes for Teat Number Relevant Traits in Duroc Pigs Using Genome-Wide Association Studies.Animals : an open access journal from MDPI · 2021Article
- Partial EMT in Squamous Cell Carcinoma: A Snapshot.International journal of biological sciences · 2021Review
- Organoid models for mammary gland dynamics and breast cancer.Current opinion in cell biology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammary gland undergoes extensive expansion of a ductal network through the stroma during puberty and is an excellent model for understanding epithelial tube morphogenesis. To investigate a role for Numb, a multifaceted adapter protein, in epithelial tube morphogenesis, we conditionally deleted it from the mammary epithelium. We report that Numb-depletion results in altered extracellular-matrix organization, reduced cell tension, altered cell shape, and increased cell packing density, which results in a 50% reduction in mammary duct elongation. Using laser ablation
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.