Evidence map›Paper›PMID 31036723›Full record

ReviewJournal of bacteriology2019

Diversity of Contact-Dependent Growth Inhibition Systems of

Jonathan P Allen, Alan R Hauser

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
  2. Journal of bacteriology · 2026
    Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Contact-Dependent Growth Inhibition in Bacteria: Do Not Get Too Close!International journal of molecular sciences · 2020
    Review
  18. A comparative genomics approach identifies contact-dependent growth inhibition as a virulence determinant.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jonathan P AllenDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA jonathan.allen@northwestern.edu.
Alan R HauserDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RICHARD G WUNDERINK · 2018 to 2026
$24.7M
Population Analysis of Pseudomonas aeruginosa VirulenceR01AI118257 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAUSER, ALAN R · 2016 to 2025
$4.9M
Mechanistic Studies of Patatin-like ToxinsR01AI053674 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAUSER, ALAN R · 2003 to 2017
$4.3M
Biomarkers for Highly Virulent Pseudomonas aeruginosa StrainsR21AI129167 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HAUSER, ALAN R · 2017 to 2018
$570k
Virulence-Associated Accessory Genomic Elements of Pseudomonas aeruginosaF32AI108247 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ALLEN, JONATHAN P · 2013 to 2014
$95k
NCATS NIH HHS UL1 TR001422NIAID NIH HHS F32 AI108247NIAID NIH HHS R01 AI053674NIAID NIH HHS R01 AI118257NIAID NIH HHS R21 AI129167NIAID NIH HHS U19 AI135964
6 · The paper itself

Abstract

Contact-dependent growth inhibition (CDI) systems are used in bacterial competition to hinder the growth of neighboring microbes. These systems utilize a two-partner secretion mechanism to display the CdiA exoprotein at the bacterial cell surface. CdiA forms a long filamentous stalk that facilitates binding to a target cell and delivery of a C-terminal toxin (CT) domain. This CT domain is processed and delivered into the cytoplasm of a target cell upon contact. CDI systems also encode a cognate immunity protein (CdiI) that protects siblings and resistant targeted cells from intoxication by high-affinity binding to the CT. CdiA CT domains vary among strains within a species, and many alleles encode enzymatic functions that target nucleic acids. This variation is thought to help drive diversity and adaptation within a species. CdiA diversity is well studied in

Indexed as

Microbial InteractionsAllelesBacterial ProteinsBacterial ToxinsEscherichia coliEscherichia coli ProteinsMembrane ProteinsPseudomonas aeruginosaBacterial ProteinsBacterial ToxinsCdiA protein, E coliEscherichia coli ProteinsMembrane Proteins

Identifiers

PMID31036723
PMCPMC6597396
OpenAlexW2941951765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.