Evidence map›Paper›PMID 31036721›Full record

ArticleBlood advances2019

Favorable outcomes with de-escalated radiation therapy for limited-stage nodular lymphocyte-predominant Hodgkin lymphoma.

Chelsea C Pinnix, Sarah A Milgrom, Chan Yoon Cheah, Jillian R Gunther, Ethan B Ludmir, Christine F Wogan, Loretta J Nastoupil, Sattva S Neelapu, Jason Westin, Hun J Lee and 10 more

Abstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Individualized patient care in nodular lymphocyte-predominant Hodgkin lymphoma.Hematology. American Society of Hematology. Education Program · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Chelsea C PinnixDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0003-3982-3664
Sarah A MilgromDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Chan Yoon CheahDepartment of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Jillian R GuntherDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Ethan B LudmirDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-5472-5344
Christine F WoganDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Loretta J NastoupilDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Sattva S NeelapuDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jason WestinDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-1824-2337
Hun J LeeDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Swaminathan P IyerDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Raphael E SteinerDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0003-3717-3629
Luis E FayadDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Nathan H FowlerDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Michael L WangDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Felipe SamaniegoDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.
Maria A RodriguezDepartment of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-3564-8697
Amy E RichOrlando Regional Medical Center, Orlando, FL; and.
L Jeffrey MedeirosDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Bouthaina S DabajaDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Radiation fields for limited-stage nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) have shrunk over time; involved-site radiation therapy (ISRT) has replaced extended-field radiation therapy (EFRT) and involved-field radiation therapy (IFRT), but this has not been validated. The role of systemic therapy is unclear. We reviewed 71 stage I/II NLPHL patients and assessed progression-free survival (PFS), overall survival (OS), locoregional disease-free survival, and distant disease-free survival (DDFS). Median patient age was 39 years, and 61% had stage II disease. Thirty-six (51%) received radiation therapy (RT) only, 6 (8%) received systemic therapy only, and 29 (41%) received both. More patients receiving combined therapy had B symptoms (

Indexed as

AdultAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyDisease-Free SurvivalFemaleHodgkin DiseaseHumansLymphocytesMaleMiddle AgedNeoplasm StagingPositron Emission Tomography Computed TomographyProportional Hazards ModelsRetrospective StudiesSurvival RateTreatment Outcome

Identifiers

PMID31036721
PMCPMC6517662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.