Evidence map›Paper›PMID 31036688›Full record

ArticleAntimicrobial agents and chemotherapy2019

Spontaneously Arising Streptococcus mutans Variants with Reduced Susceptibility to Chlorhexidine Display Genetic Defects and Diminished Fitness.

Justin R Kaspar, Matthew J Godwin, Irina M Velsko, Vincent P Richards, Robert A Burne

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. In Vitro Bacterial Competition ofAntibiotics (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. A Comparison of the Adaptive Response ofFrontiers in microbiology · 2022
    Article
  10. Article
  11. The LactococcalInternational journal of molecular sciences · 2021
    Article
  12. Article
  13. Article
  14. 2CS-CHXApplied and environmental microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Justin R KasparDepartment of Oral Biology, University of Florida, Gainesville, Florida, USA jkaspar@dental.ufl.edu.ORCID 0000-0001-6901-5524
Matthew J GodwinDepartment of Oral Biology, University of Florida, Gainesville, Florida, USA.
Irina M VelskoDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, USA.ORCID 0000-0001-9810-9917
Vincent P RichardsDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, USA.
Robert A BurneDepartment of Oral Biology, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-4234-0316
University of Florida · USClemson University · USMax Planck Institute for the Science of Human History · DE

Funding

Comprehensive Training Program in Oral BiologyT90DE021990 · NIDCR · UNIVERSITY OF FLORIDA · PI Jose A Lemos · 2011 to 2026
$8.2M
GENETICS AND PHYSIOLOGY OF ORAL BIOFILMSR01DE013239 · NIDCR · UNIVERSITY OF ROCHESTER · PI BURNE, ROBERT A · 1999 to 2019
$6.6M
Probiotics that moderate pH and antagonize pathogens to promote oral healthR01DE025832 · NIDCR · UNIVERSITY OF FLORIDA · PI BURNE, ROBERT A · 2016 to 2020
$3.4M
Environmental regulation of gene expression dissected by microfluidicsR01DE023339 · NIDCR · UNIVERSITY OF FLORIDA · PI BURNE, ROBERT A, HAGEN, STEPHEN JAMES · 2014 to 2018
$1.9M
Integration of Stress Tolerance in Competence DevelopmentF31DE024416 · NIDCR · UNIVERSITY OF FLORIDA · PI KASPAR, JUSTIN RAY · 2014 to 2015
$74k
Ecological Consequences of Cell-Cell Signaling on Interbacterial CompetitionF32DE028479 · NIDCR · UNIVERSITY OF FLORIDA · PI KASPAR, JUSTIN RAY · 2018 to 2018
$60k
NIDCR NIH HHS F31 DE024416NIDCR NIH HHS F32 DE028479NIDCR NIH HHS R01 DE013239NIDCR NIH HHS R01 DE023339NIDCR NIH HHS R01 DE025832NIDCR NIH HHS T90 DE021990
6 · The paper itself

Abstract

Chlorhexidine (CHX) has been used to control dental caries caused by acid-tolerant bacteria such as

Indexed as

Anti-Bacterial AgentsChlorhexidineClindamycinDaptomycinDental CariesHydrogen PeroxideMicrobial Sensitivity TestsPolymorphism, Single NucleotideStreptococcus mutansWhole Genome SequencingAnti-Bacterial AgentsChlorhexidineClindamycinDaptomycinHydrogen Peroxideantimicrobialsantimicrobial tolerancebiofilmschlorhexidinedental cariesmicrobial antagonismoral microbiomeStreptococcus mutansstress response

Identifiers

PMID31036688
PMCPMC6591629
OpenAlexW2942165430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.