Evidence map›Paper›PMID 31036664›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

PGE

Qingkun Liu, Xibin Liang, Qian Wang, Edward N Wilson, Rachel Lam, Jing Wang, William Kong, Connie Tsai, Tingting Pan, Paul B Larkin and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Pooled it
  2. Article
  3. Article
  4. Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026
    Article
  5. Neuroinflammation and Disease: Pathways and Opportunities.Annual review of pharmacology and toxicology · 2026
    Review
  6. Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes.Metabolomics : Official journal of the Metabolomic Society · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Chronic Treatment withInternational journal of molecular sciences · 2024
    Article
  13. Review
  14. Article
  15. Review
  16. Neuroinflammatory mediators in acquired epilepsy: an update.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Qingkun LiuDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
Xibin LiangDepartment of Neurosurgery, Comparative Medicine, and Neurology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
Qian WangDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
Edward N WilsonDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
Rachel LamDepartment of Neurosurgery, Comparative Medicine, and Neurology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
Jing WangDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
William KongInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305.
Connie TsaiDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.ORCID 0000-0002-7779-5855
Tingting PanDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
Paul B LarkinDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
Mehrdad ShamlooDepartment of Neurosurgery, Comparative Medicine, and Neurology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305.
Katrin I AndreassonDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA 94305; kandreas@stanford.edu.ORCID 0000-0001-8391-4155
Stanford University · USCalifornia Institute for Regenerative Medicine · USNeurosciences Institute · US

Funding

Protective Prostaglandin Receptors in Cerebral IschemiaR01NS045727 · NINDS · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2004 to 2015
$3.7M
Modulating the post-stroke inflammatory response to improve outcome in models of cerebral ischemiaR01NS100180 · NINDS · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2018 to 2021
$1.8M
Microglial and macrophage PGE2 signaling in post-stroke inflammationR21NS087639 · NINDS · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2014 to 2015
$449k
Therapeutic functions of prostaglandin signaling in post-stroke inflammationF32NS086397 · NINDS · STANFORD UNIVERSITY · PI LARKIN, PAUL · 2014 to 2014
$38k
NINDS NIH HHS F32 NS086397NINDS NIH HHS N01 NS002331NINDS NIH HHS R01 NS045727NINDS NIH HHS R01 NS100180NINDS NIH HHS R21 NS087639
6 · The paper itself

Abstract

The inflammatory prostaglandin E2 (PGE

Indexed as

AnimalsBrain IschemiaCognitionDinoprostoneDisease Models, AnimalDrug Evaluation, PreclinicalFemaleImmunity, InnateMaleMice, Inbred C57BLMyeloid CellsNeuronsReceptors, Prostaglandin E, EP2 SubtypeDinoprostoneReceptors, Prostaglandin E, EP2 Subtypeconditional knockoutPGE2stroke

Identifiers

PMID31036664
PMCPMC6525498
OpenAlexW2943015186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.