Evidence map›Paper›PMID 31036644›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Regulatory T cells limit unconventional memory to preserve the capacity to mount protective CD8 memory responses to pathogens.

Andreia S Da Costa, Jessica B Graham, Jessica L Swarts, Jennifer M Lund

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Signals for antigen-independent differentiation of memory CD8Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andreia S Da CostaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Jessica B GrahamVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Jessica L SwartsVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Jennifer M LundVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109; jlund@fredhutch.org.ORCID 0000-0003-3284-979X

Funding

Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HEISE, MARK T · 2012 to 2021
$36.6M
Diseases of Public Health Importance Training GrantT32AI007509 · NIAID · UNIVERSITY OF WASHINGTON · PI LUND, JENNIFER M · 1997 to 2024
$6.3M
Immunoprotective Properties of Tissue-resident Memory T Cells in Mice and Humans within Mucosal SitesR01AI121129 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LUND, JENNIFER M, PRLIC, MARTIN · 2016 to 2022
$5.0M
Tissue Regulatory T Cells in Mucosal InfectionR01AI141435 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LUND, JENNIFER M · 2019 to 2023
$3.2M
Regulatory T cell Modulation of Immunity to Mucosal Viral InfectionsR01AI087657 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LUND, JENNIFER M · 2010 to 2014
$2.2M
NIAID NIH HHS R01 AI087657NIAID NIH HHS R01 AI121129NIAID NIH HHS R01 AI141435NIAID NIH HHS T32 AI007509NIAID NIH HHS U19 AI100625
6 · The paper itself

Abstract

Immunological memory exists so that following infection an expanded population of pathogen-specific lymphocytes can rapidly and efficiently control infection in the case of reexposure. However, in the case of CD8+ T lymphocytes, a population of unconventional CD44+CD122+ virtual memory T cells (T

Indexed as

Immunologic MemoryAnimalsCD8-Positive T-LymphocytesCTLA-4 AntigenDendritic CellsIntegrin beta1Interleukin-15MaleMiceT-Lymphocytes, RegulatoryCTLA-4 AntigenIntegrin beta1Interleukin-15IL-15regulatory T cellsunconventional memory T cellsvirtual memory T cellsvirus infection

Identifiers

PMID31036644
PMCPMC6525503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.