Evidence map›Paper›PMID 31036624›Full record

ArticleAnnals of the rheumatic diseases2019

Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for

Athina Spiliopoulou, Marco Colombo, Darren Plant, Nisha Nair, Jing Cui, Marieke Jh Coenen, Katsunori Ikari, Hisashi Yamanaka, Saedis Saevarsdottir, Leonid Padyukov and 22 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  9. Article
  10. Review
  11. Towards Personalized Medicine in Rheumatoid Arthritis.Open access rheumatology : research and reviews · 2024
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 8 countries.

Athina SpiliopoulouUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK A.Spiliopoulou@ed.ac.uk Paul.McKeigue@ed.ac.uk.ORCID 0000-0002-5929-6585
Marco ColomboUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Darren PlantArthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Nisha NairArthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Jing CuiDivision of Rheumatology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Marieke Jh CoenenDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Katsunori IkariDepartment of Orthopedic Surgery, Tokyo Women's Medical University, Tokyo, Japan.
Hisashi YamanakaDepartment of Rheumatology, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Saedis SaevarsdottirDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Leonid PadyukovDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
S Louis BridgesDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Robert P KimberlyDivision of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Piet L Cm van RielDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Gertjan WolbinkAmsterdam Rheumatology and Immunology Centre, Reade, Amsterdam, The Netherlands.
Irene E van der Horst-BruinsmaDepartment of Rheumatology, VU University Medical Centre, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Niek de VriesDepartment of Clinical Immunology and Rheumatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Paul P TakDepartment of Clinical Immunology and Rheumatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Koichiro OhmuraDepartment of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Helena CanhãoCEDOC, EpiDoC Unit, NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal.
Henk-Jan GuchelaarDepartment of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.
Tom Wj HuizingaDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Lindsey A CriswellRosalind Russell / Ephraim P Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, California, USA.
Soumya RaychaudhuriDivision of Rheumatology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Michael E WeinblattDivision of Rheumatology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Anthony G WilsonEULAR Centre of Excellence/UCD Centre for Arthritis Research, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Xavier Mariettey Université Paris-Sud, INSERM UMR1184, Hôpitaux Universitaire Paris-Sud, AP-HP, Le Kremlin Bicêtre, Paris, France.
John D IsaacsInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Ann W MorganSchool of Medicine, University of Leeds, Leeds, UK.
Costantino PitzalisCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK.ORCID 0000-0003-1326-5051
Anne BartonArthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Paul McKeigueUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK A.Spiliopoulou@ed.ac.uk Paul.McKeigue@ed.ac.uk.
Brigham and Women's Hospital · USManchester Academic Health Science Centre · GBKarolinska University Hospital · SELeiden University Medical Center · NLRadboud University Nijmegen · NLUniversity of Alabama at Birmingham · USUniversity of Amsterdam · NLUniversity of Edinburgh · GBInstitute of Genetics and Cancer · GBJapan Science and Technology Agency · JPKyoto University · JPNewcastle upon Tyne Hospitals NHS Foundation Trust · GBQueen Mary University of London · GBReade · NLThe University of Osaka · JPTokyo Women's Medical University · JPUniversidade Nova de Lisboa · PTUniversité Paris-Sud · FRUniversity College Dublin · IEUniversity of California, San Francisco · US

Funding

RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
Genetic predictors of response to anti-TNF therapy in rheumatoid arthritisU01GM092691 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2010 to 2014
$7.5M
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4M
Arthritis Research UKMedical Research Council MR/K015346/1NIAMS NIH HHS P30 AR070155NIAMS NIH HHS R01 AR063759NIGMS NIH HHS U01 GM092691
6 · The paper itself

Abstract

objectivesWe sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these genetic loci for stratifying drug response.

methodsWe studied the relation of TNFi response, quantified by change in swollen joint counts ( Δ SJC) and erythrocyte sedimentation rate ( Δ ESR) with locus-specific scores constructed from genome-wide assocation study summary statistics in 2938 genotyped individuals: 37 scores for RA; scores for 19 immune cell traits; scores for expression or methylation of 93 genes with previously reported associations between transcript level and drug response. Multivariate associations were evaluated in penalised regression models by cross-validation.

resultsWe detected a statistically significant association between Δ SJC and the RA score at the

conclusionsThe association with the CD39 trait is difficult to interpret because patients with RA are often prescribed TNFi after failing to respond to methotrexate. The CD39 and

Indexed as

AdultAgedAntigens, CDAntirheumatic AgentsApyraseArthritis, RheumatoidBiological ProductsCD40 AntigensCohort StudiesFemaleGene Expression RegulationGenome-Wide Association StudyHumansMaleMiddle AgedMolecular Targeted TherapyAntigens, CDAntirheumatic AgentsApyraseBiological ProductsCD39 antigenCD40 AntigensTumor Necrosis Factor Inhibitorsanti-tnfpharmacogeneticsrheumatoid arthritis

Identifiers

PMID31036624
PMCPMC6669378
OpenAlexW2943094354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.