Evidence map›Paper›PMID 31036623›Full record

ArticleAnnals of the rheumatic diseases2019

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink.

Georgina Nakafero, Matthew J Grainge, Puja R Myles, Christian D Mallen, Weiya Zhang, Michael Doherty, Jonathan S Nguyen-Van-Tam, Abhishek Abhishek

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Georgina NakaferoAcademic Rheumatology, University of Nottingham, Nottingham, UK georgina.nakafero@nottingham.ac.uk.ORCID 0000-0002-3859-7354
Matthew J GraingeDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Puja R MylesDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Christian D MallenPrimary Care Centre Versus Arthritis, Keele University, Keele, UK.
Weiya ZhangAcademic Rheumatology, University of Nottingham, Nottingham, UK.
Michael DohertyAcademic Rheumatology, University of Nottingham, Nottingham, UK.
Jonathan S Nguyen-Van-TamDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Abhishek AbhishekAcademic Rheumatology, University of Nottingham, Nottingham, UK.
University of Nottingham · GBArthritis UK · GB

Funding

Arthritis Research UKDepartment of Health RP_2014-04-026Department of Health RP-PG-0617-20005Versus Arthritis 21297
6 · The paper itself

Abstract

ObjectivesTo examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis and unexplained fever in people with autoimmune rheumatic diseases (AIRDs).

methodsWe undertook within-person comparisons using self-controlled case-series methodology. AIRD cases who received the IIV and had an outcome of interest in the same influenza cycle were ascertained in Clinical Practice Research Datalink. The influenza cycle was partitioned into exposure periods (1-14 days prevaccination and 0-14, 15-30, 31-60 and 61-90 days postvaccination), with the remaining time-period classified as non-exposed. Incidence rate ratios (IRR) and 95% CI for different outcomes were calculated.

resultsData for 14 928 AIRD cases (69% women, 80% with RA) were included. There was no evidence for association between vaccination and primary care consultation for RA flare, corticosteroid prescription, fever or vasculitis. On the contrary, vaccination associated with reduced primary care consultation for joint pain in the subsequent 90 days (IRR 0.91 (95% CI 0.87 to 0.94)).

conclusionThis study found no evidence for a significant association between vaccination and primary care consultation for most surrogates of increased disease activity or vaccine adverse-effects in people with AIRDs. It adds to the accumulating evidence to support influenza vaccination in AIRDs.

Indexed as

Disease ProgressionAutoimmune DiseasesCase-Control StudiesDatabases, FactualFemaleFeverFollow-Up StudiesHumansInfluenza, HumanInfluenza VaccinesMalePatient SafetyPrimary Health CareReference ValuesReferral and ConsultationRheumatic DiseasesInfluenza VaccinesVaccines, Inactivatedautoimmune diseasesrheumatoid arthritisvaccination

Identifiers

PMID31036623
PMCPMC6691866
OpenAlexW2942642518

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.