ArticleBioscience reports2019
Differential expression and bioinformatics analysis of circRNA in osteosarcoma.
Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The trial behind it
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Who cites it
35 citing papers in PubMed.
- Hsa_circ_0003611 hinders the transformation of mesenchymal stem cells into osteosarcoma cells through suppressing MYC by IGF2BP3 via mBiological research · 2025Article
- Research progress of circRNAs in bone-related diseases.Frontiers in oncology · 2025Review
- A prognostic framework integrating endoplasmic reticulum stress dynamics reveals clinical stratification and differential prognostic attributes in osteosarcoma patients.Frontiers in medicine · 2025Article
- CircRNA-CIRH1A Promotes the Development of Osteosarcoma by Regulating PI3K/AKT and JAK2/STAT3 Signaling Pathways.Molecular biotechnology · 2024Article
- Article
- Oncogenic miR-106b-5p promotes cisplatin resistance in triple-negative breast cancer by targeting GDF11.Histology and histopathology · 2024Article
- Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma.Cancer biomarkers : section A of Disease markers · 2024Article
- hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression.Cancer biology & therapy · 2023Article
- Analysis of CircRNA Expression in Peripheral Blood of Holstein Cows in Response to Heat Stress.International journal of molecular sciences · 2023Article
- Computational approaches for circRNAs prediction and in silico characterization.Briefings in bioinformatics · 2023Review
- Characterization of Growth Secondary Hair in Min Pig Activated by Follicle Stem Cell Stimulated by Wnt and BMP Signaling Pathway.Animals : an open access journal from MDPI · 2023Article
- Article
- Low expression of IGFBP4 and TAGLN accelerate the poor overall survival of osteosarcoma.Scientific reports · 2022Article
- The regulatory mechanism of LncRNA-mediated ceRNA network in osteosarcoma.Scientific reports · 2022Article
- CircRNA protein tyrosine phosphatase receptor type a suppresses proliferation and induces apoptosis of lung adenocarcinoma cells via regulation of microRNA-582-3p.Bioengineered · 2022Article
- Screening and identification of osteoarthritis related differential genes and construction of a risk prognosis model based on bioinformatics analysis.Annals of translational medicine · 2022Article
- Circular RNA circ_0002137 regulated the progression of osteosarcoma through regulating miR-433-3p/ IGF1R axis.Journal of cellular and molecular medicine · 2022Article
- CircAGFG1 Promotes Osteosarcoma Progression and Stemness by Competing with miR-302a-3p to Upregulate the Expression of LATS2.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Hsa_circ_0008259 modulates miR-21-5p and PDCD4 expression to restrain osteosarcoma progression.Aging · 2021Article
- Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis research aims to investigate the expression profile of circRNA in osteosarcoma and to identify the underlying pathogenesis core genes of osteosarcoma.Methods
resultsA total of 259 differentially expressed circRNAs were evaluated in patients with osteosarcoma, of which 132 were up-regulated and 127 were down-regulated. Compared with that in paracancerous tissues, circ_32279 and circ_24831 were significantly down-regulated while circ_2137 and circ_20403 were significantly up-regulated in osteosarcoma tissues. The differential expression of circRNA is closely linked to biological processes and molecular functions. The difference in circRNA was mainly linked to the 'phosphatidylinositol signalling system' signal pathway and the 'inositol phosphate metabolism' signal pathway.
conclusionThe present study identified a profile of abnormal regulation of circRNA in osteosarcoma. Bioinformatics analysis indicates that the deregulated circRNAs may be related to the occurrence and development of osteosarcoma.
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Registered trials
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