ArticleBMJ (Clinical research ed.)2019
Pre-eclampsia and risk of later kidney disease: nationwide cohort study.
Article in BMJ (Clinical research ed.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 6 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 6 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- The dilemma of chronic kidney disease and end-stage kidney disease following pre-eclampsia: a literature review and meta-analysis.International urology and nephrology · 2025Pooled it
- A systematic review on the determinants of long-term kidney sequelae after hypertensive diseases of pregnancy.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- Urinary nephrin-a potential marker of early glomerular injury: a systematic review and meta-analysis.Journal of nephrology · 2024Pooled it
- Prevention and Screening for Cardiometabolic Disease Following Hypertensive Disorders in Pregnancy in Low-Resource Settings: A Systematic Review and Delphi Study.Global heart · 2023Pooled it
- Pooled it
- Adverse Pregnancy Outcomes and Long-term Maternal Kidney Disease: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Adverse pregnancy outcomes, longitudinal change in eGFR, and incident hypertension in women: a population-based cohort study.Renal failure · 2026Article
- Hypertension Management in Pregnancy and Postpartum.Journal of the American Society of Nephrology : JASN · 2026Review
- Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease: A Population-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Hypertensive Disorders of Pregnancy and Cardiovascular-Kidney-Metabolic Syndrome.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Divergent Risk Factors and Outcomes in Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome and Isolated Preeclampsia.Kidney international reports · 2026Article
- The pathophysiology of pre-eclampsia.Nature reviews. Nephrology · 2026Review
- Laboratory Signs of CKD after Preeclampsia.Journal of the American Society of Nephrology : JASN · 2026Article
- Gestational Diabetes Mellitus and Incident Kidney Disease: A Nationwide French Cohort Study.Kidney360 · 2026Article
- Abnormal renal function three months after delivery among pre-eclampsia survivors in Sub-Saharan Africa: a prospective cohort study in Uganda.BMC pregnancy and childbirth · 2026Article
- Nephrology Survey on Reproductive Health and Kidney Disease.Kidney international reports · 2026Article
- Preeclampsia and Onset of Renal Disorders in the Long-Term Period following Pregnancy.American journal of nephrology · 2026Article
- Subclinical Postpartum Renal Structure After Hypertensive Pregnancy Disorders.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Comparison of first trimester preeclampsia combined screening performances with various approaches in the Indonesian population.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Development and Validation of a Predictive Model for Maternal Cardiovascular Morbidity Events in Patients With Hypertensive Disorders of Pregnancy.Anesthesia and analgesia · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate associations between pre-eclampsia and later risk of kidney disease.
designNationwide register based cohort study.
settingDenmark. POPULATION: All women with at least one pregnancy lasting at least 20 weeks between 1978 and 2015.
main outcome measureHazard ratios comparing rates of kidney disease between women with and without a history of pre-eclampsia, stratified by gestational age at delivery and estimated using Cox regression.
resultsThe cohort consisted of 1 072 330 women followed for 19 994 470 person years (average 18.6 years/woman). Compared with women with no previous pre-eclampsia, those with a history of pre-eclampsia were more likely to develop chronic renal conditions: hazard ratio 3.93 (95% confidence interval 2.90 to 5.33, for early preterm pre-eclampsia (delivery <34 weeks); 2.81 (2.13 to 3.71) for late preterm pre-eclampsia (delivery 34-36 weeks); 2.27 (2.02 to 2.55) for term pre-eclampsia (delivery ≥37 weeks). In particular, strong associations were observed for chronic kidney disease, hypertensive kidney disease, and glomerular/proteinuric disease. Adjustment for cardiovascular disease and hypertension only partially attenuated the observed associations. Stratifying the analyses on time since pregnancy showed that associations between pre-eclampsia and chronic kidney disease and glomerular/proteinuric disease were much stronger within five years of the latest pregnancy (hazard ratio 6.11 (3.84 to 9.72) and 4.77 (3.88 to 5.86), respectively) than five years or longer after the latest pregnancy (2.06 (1.69 to 2.50) and 1.50 (1.19 to 1.88). By contrast, associations between pre-eclampsia and acute renal conditions were modest.
conclusions Pre-eclampsia, particularly early preterm pre-eclampsia, was strongly associated with several chronic renal disorders later in life. More research is needed to determine which women are most likely to develop kidney disease after pre-eclampsia, what mechanisms underlie the association, and what clinical follow-up and interventions (and in what timeframe post-pregnancy) would be most appropriate and effective.
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