Evidence map›Paper›PMID 31036554›Full record

ArticleThe EMBO journal2019

Human keratin 1/10-1B tetramer structures reveal a knob-pocket mechanism in intermediate filament assembly.

Sherif A Eldirany, Minh Ho, Alexander J Hinbest, Ivan B Lomakin, Christopher G Bunick

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 52 citations in OpenAlex.

  1. Vimentin Dynamics in Viral Infection: Shield or Sabotage?International journal of molecular sciences · 2025
    Review
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  9. Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Article
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  15. Keratin 1 as a cell-surface receptor in cancer.Biochimica et biophysica acta. Reviews on cancer · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Recent insight into intermediate filament structure.Current opinion in cell biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sherif A EldiranyDepartment of Dermatology, Yale University, New Haven, CT, USA.
Minh HoDepartment of Dermatology, Yale University, New Haven, CT, USA.
Alexander J HinbestDepartment of Dermatology, Yale University, New Haven, CT, USA.
Ivan B LomakinDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Christopher G BunickDepartment of Dermatology, Yale University, New Haven, CT, USA christopher.bunick@yale.edu.ORCID 0000-0002-4011-8308
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Determining Structure and Function of Human Skin Barrier Proteins Using X-ray CrystallographyK08AR070290 · NIAMS · YALE UNIVERSITY · PI BUNICK, CHRISTOPHER GERARD · 2016 to 2020
$754k
NCATS NIH HHS UL1 TR001863NIAMS NIH HHS K08 AR070290
6 · The paper itself

Abstract

To characterize keratin intermediate filament assembly mechanisms at atomic resolution, we determined the crystal structure of wild-type human keratin-1/keratin-10 helix 1B heterotetramer at 3.0 Å resolution. It revealed biochemical determinants for the A

Indexed as

Keratin-1Keratin-10Protein Interaction Domains and MotifsAmino Acid SubstitutionCircular DichroismCrystallography, X-RayCytoskeletonDynamic Light ScatteringHumansHydrophobic and Hydrophilic InteractionsIntermediate Filament ProteinsModels, MolecularMutation, MissenseProtein FoldingProtein MultimerizationProtein Structure, QuaternaryIntermediate Filament ProteinsKeratin-1Keratin-10KRT10 protein, humanintermediate filamentkeratinskin diseasestructurevimentin

Identifiers

PMID31036554
PMCPMC6545558
OpenAlexW2943595942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.