ArticleTechnology in cancer research & treatment2019
The Differentiation of Soft Tissue Infiltration and Surrounding Edema in an Animal Model of Malignant Bone Tumor: Evaluation by Dual-Energy CT.
Article in Technology in cancer research & treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 18 citations in OpenAlex.
- Diagnostic accuracy of dual-energy CT virtual non-calcium imaging for detecting spinal metastases: a retrospective comparison with conventional CT.Skeletal radiology · 2026Article
- Establishment of orthotopic osteosarcoma animal models in immunocompetent rats through muti-rounds of in-vivo selection.BMC cancer · 2024Article
- Methods of ex vivo analysis of tissue status in vascularized composite allografts.Journal of translational medicine · 2023Review
- Application of modified closed biopsy in rabbit model of VX2-transplanted bone tumor.Journal of orthopaedic surgery and research · 2021Article
- A CT-based radiomics nomogram for distinguishing between benign and malignant bone tumours.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Evaluating the scope of intramedullary invasion of malignant bone tumor by DCE-MRI quantitative parameters in animal study.Journal of bone oncology · 2019Article
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7 authors at 1 institution in 1 country.
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Abstract
To study the value of dual energy computed tomography in distinguishing soft tissue infiltration from surrounding soft tissue edema in rabbit malignant bone tumor, a malignant bone tumor model was established through implantation of VX2 tumor fragments into the tibiae of rabbits. Tumor adjacent soft tissues were divided into 3 areas according to pathology and computed tomography images. Computed tomography spectral curve slopes and iodine and water concentrations were assessed. Statistical analyses were performed using the Mann-Whitney U test and t test. The spectral curve of the soft tissue infiltration areas has a slope (1.30 ± 0.41) higher than that of the soft tissue edema areas (0.71 ± 0.23; P < .001). The iodine concentration in the soft tissue infiltration areas (8.56 ± 2.15) was higher than that in the in soft tissue edema areas (6.09 ± 1.02; P < .001). Water concentration was similar in the soft tissue infiltration areas (1033.86 ± 10.50) to that of the edema areas (1031.45 ± 12.83; P < .05). Spectral curve analysis and iodine-water concentration are helpful in the differentiation of bone tumor soft tissue infiltration and soft tissue edema.
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