Evidence map›Paper›PMID 31035694›Full record

ReviewMolecules (Basel, Switzerland)2019

Antispasmodic Effect of Essential Oils and Their Constituents: A Review.

Simona Codruta Heghes, Oliviu Vostinaru, Lucia Maria Rus, Cristina Mogosan, Cristina Adela Iuga, Lorena Filip

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 80 citations in OpenAlex.

  1. Article
  2. A Bioactive Benzyl Terpene fromMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
  4. The Effects of Sage (Veterinary sciences · 2025
    Article
  5. Expert Opinion on the Efficacy and Safety of Antispasmodics with a Focus on Irritable Bowel Syndrome.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Antispasmodic Effect ofPharmaceutics · 2023
    Article
  17. Article
  18. Hypokinetic Activity of Menthofuran on the Gastrointestinal Tract in Rodents.Evidence-based complementary and alternative medicine : eCAM · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Simona Codruta HeghesDepartment of Drug Analysis, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. cmaier@umfcluj.ro.
Oliviu VostinaruDepartment of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. oliviu_vostinaru@yahoo.com.
Lucia Maria RusDepartment of Drug Analysis, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. lrus@umfcluj.ro.
Cristina MogosanDepartment of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. cmogosan@umfcluj.ro.
Cristina Adela IugaDepartment of Drug Analysis, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. iugac@umfcluj.ro.
Lorena FilipDepartment of Bromatology, Hygiene, Nutrition, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca 400349, Romania. lfilip@umfcluj.ro.
Iuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antispasmodic effect of drugs is used for the symptomatic treatment of cramping and discomfort affecting smooth muscles from the gastrointestinal, billiary or genitourinary tract in a variety of clinical situations.The existing synthetic antispasmodic drugs may cause a series of unpleasant side effects, and therefore the discovery of new molecules of natural origin is an important goal for the pharmaceutical industry. This review describes a series of recent studies investigating the antispasmodic effect of essential oils from 39 plant species belonging to 12 families. The pharmacological models used in the studies together with the mechanistic discussions and the chemical composition of the essential oils are also detailed. The data clearly demonstrate the antispasmodic effect of the essential oils from the aromatic plant species studied. Further research is needed in order to ascertain the therapeutic importance of these findings.

Indexed as

AnimalsCalcium Channel BlockersCalcium ChannelsClinical Studies as TopicCyclic AMPDrug Evaluation, PreclinicalHumansMolecular StructureMuscle ContractionMuscle, SmoothOils, VolatileParasympatholyticsPhytochemicalsPlant ExtractsStructure-Activity RelationshipTreatment OutcomeCalcium Channel BlockersCalcium ChannelsCyclic AMPOils, VolatileParasympatholyticsPhytochemicalsPlant Extractsantispasmodic effectaromatic plantsessential oilsisolated ileummonoterpenes

Identifiers

PMID31035694
PMCPMC6539827
OpenAlexW2941373250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.