Evidence map›Paper›PMID 31035684›Full record

ReviewInternational journal of molecular sciences2019

The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder.

Piranavie Srikantha, M Hasan Mohajeri

3 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 207 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 10 pooled it
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06200935 completednot on this mapstarted 2021, after this paper: background citation

Results of the Action of a Combination of Probiotics on the Microbiota and Intestinal Permeability in Children With Neurodevelopmental Disorders and Their Influence on the Improvement of Language, Behavioral Evolution and Learning

TypeobservationalSponsorInstituto de Genética Médica y MolecularRan2021 to 2022Enrolled90ConditionsNeurodevelopmental DisordersArmsProbiotic blend
NCT06568588 phase2active not recruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Probiotic Consumption in Children With Autism Spectrum Disorder (ASD) in the Metropolitan District of Quito, Ecuador

TypeinterventionalSponsorUniversidad San Francisco de QuitoRan2024 to 2026Enrolled66ConditionsAutism Spectrum DisorderArmsS. boulardii CNCM (National Collection of Cultures of Microorganisms) I-745
NCT07086157 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Low-FODMAP Diet and Probiotics on Gastrointestinal Symptoms, Behavior Problems, and Microbiota in Children With Autism Spectrum Disorder and Gastrointestinal Symptoms

TypeinterventionalSponsorMarmara University Pendik Training and Research HospitalRan2023 to 2024Enrolled16ConditionsAutism Spectrum Disorder, Functional Gastrointestinal DisordersArmsProbiotic, Low-FODMAP Diet
3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 10 syntheses or guidelines pooled it, 393 citations in OpenAlex.

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  5. Microbiota in Autism Spectrum Disorder: A Systematic Review.International journal of molecular sciences · 2023
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147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Piranavie SrikanthaDepartment of medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland. piranavie.srikantha@uzh.ch.
M Hasan MohajeriDepartment of medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland. mhasan.mohajeri@uzh.ch.
University of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New research points to a possible link between autism spectrum disorder (ASD) and the gut microbiota as many autistic children have co-occurring gastrointestinal problems. This review focuses on specific alterations of gut microbiota mostly observed in autistic patients. Particularly, the mechanisms through which such alterations may trigger the production of the bacterial metabolites, or leaky gut in autistic people are described. Various altered metabolite levels were observed in the blood and urine of autistic children, many of which were of bacterial origin such as short chain fatty acids (SCFAs), indoles and lipopolysaccharides (LPS). A less integrative gut-blood-barrier is abundant in autistic individuals. This explains the leakage of bacterial metabolites into the patients, triggering new body responses or an altered metabolism. Some other co-occurring symptoms such as mitochondrial dysfunction, oxidative stress in cells, altered tight junctions in the blood-brain barrier and structural changes in the cortex, hippocampus, amygdala and cerebellum were also detected. Moreover, this paper suggests that ASD is associated with an unbalanced gut microbiota (dysbiosis). Although the cause-effect relationship between ASD and gut microbiota is not yet well established, the consumption of specific probiotics may represent a side-effect free tool to re-establish gut homeostasis and promote gut health. The diagnostic and therapeutic value of bacterial-derived compounds as new possible biomarkers, associated with perturbation in the phenylalanine metabolism, as well as potential therapeutic strategies will be discussed.

Indexed as

Gastrointestinal MicrobiomeAnimalsAutism Spectrum DisorderBiodiversityBrainChildComorbidityHumansIntestinal MucosaIntestinesMetabolic Networks and PathwaysMetabolomicsMitochondriaPrebioticsProbioticsRisk FactorsPrebioticsASDAutismgut-brain-axismicrobiotamicrobiota-gut-brain-axisprebioticsprobiotics

Identifiers

PMID31035684
PMCPMC6539237
OpenAlexW2943088522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.