Evidence map›Paper›PMID 31035658›Full record

ArticleCancers2019

Polymorphisms of Mismatch Repair Pathway Genes Predict Clinical Outcomes in Oral Squamous Cell Carcinoma Patients Receiving Adjuvant Concurrent Chemoradiotherapy.

Thomas Senghore, Wen-Chang Wang, Huei-Tzu Chien, You-Xin Chen, Chi-Kuang Young, Shiang-Fu Huang, Chih-Ching Yeh

Abstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Genetic Variation ofInternational journal of dentistry · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Do non-pathogenic variants of DNA mismatch repair genes modify neurofibroma load in neurofibromatosis type 1?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
    Review
  7. Gene polymorphisms and prognosis of head and neck squamous cell carcinoma: a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas SenghoreDepartment of Public Health, School of Public Health, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan. tsenghore@gmail.com.ORCID 0000-0002-9846-9485
Wen-Chang WangPh.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11301, Taiwan. wangwc@tmu.edu.tw.
Huei-Tzu ChienDepartment of Public Health, Chang Gung University, Taoyuan 33305, Taiwan. kathy.htchien@gmail.com.ORCID 0000-0002-4120-7070
You-Xin ChenDepartment of Public Health, School of Public Health, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan. youxin810@gmail.com.
Chi-Kuang YoungDepartment of Otolaryngology, Chang Gung Memorial Hospital, Keelung 20401, Taiwan. rioriorioman@gmail.com.
Shiang-Fu HuangDepartment of Public Health, Chang Gung University, Taoyuan 33305, Taiwan. shiangfu.huang@gmail.com.ORCID 0000-0003-3582-9938
Chih-Ching YehDepartment of Public Health, School of Public Health, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan. ccyeh@tmu.edu.tw.ORCID 0000-0001-6483-1100

Funding

Chang Gung Memorial Hospital, Taiwan CMRPG3H0791 and CMRPB53Ministry of Health and Welfare MOHW108-TDU-B-212-124016Ministry of Science and Technology, Taiwan MOST 107-2314-B-038-071 and MOST 106-2314-B-182-025-MY3
6 · The paper itself

Abstract

backgroundWe aimed to investigate the association between single-nucleotide polymorphisms (SNP) in mismatch repair (MMR) pathway genes and survival in patients with oral squamous cell carcinoma (OSCC) who received adjuvant concurrent chemoradiotherapy (CCRT).

methodsUsing the Sequenom iPLEX MassARRAY system, five SNPs in four major MMR genes were genotyped in 319 patients with OSCC who received CCRT treatment. Kaplan-Meier survival curves and Cox proportional hazard regression models were used to assess overall survival (OS) and disease-free survival (DFS) among MMR genotypes.

resultsThe results of Kaplan-Meier survival analysis revealed that the MutS homolog 2

conclusionsOur results indicated that the GG genotypes of

Indexed as

clinical outcomeconcurrent chemoradiotherapymismatch repair geneoral squamous cell carcinomasingle-nucleotide polymorphism

Identifiers

PMID31035658
PMCPMC6562473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.