Evidence map›Paper›PMID 31035643›Full record

ArticleViruses2019

Adeno-Associated Virus VP1u Exhibits Protease Activity.

Justin J Kurian, Renuk Lakshmanan, William M Chmely, Joshua A Hull, Jennifer C Yu, Antonette Bennett, Robert McKenna, Mavis Agbandje-McKenna

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. AAV vector development, back to the future.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Cryo-EM structure of adeno-associated virus 4 at 2.2 Å resolution.Acta crystallographica. Section D, Structural biology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Justin J KurianDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. justinkurian@ufl.edu.
Renuk LakshmananDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. renuk@ufl.edu.
William M ChmelyDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. wchmely0812@ufl.edu.
Joshua A HullDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. the.hegemon@ufl.edu.
Jennifer C YuDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. jennifer.yu@ufl.edu.
Antonette BennettDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. dendena@ufl.edu.
Robert McKennaDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. rmckenna@ufl.edu.ORCID 0000-0002-2792-935X
Mavis Agbandje-McKennaDepartment of Biochemistry and Molecular Biology, Center for Structural Biology, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. mckenna@ufl.edu.
University of Florida · US

Funding

BASIC MICROBIOLOGY &INFECTIOUS DISEASEST32AI007110 · NIAID · UNIVERSITY OF FLORIDA · PI Stephanie M Karst · 1985 to 2026
$4.3M
Structure and dynamics of the VP1u infectivity domain of the ParvoviridaeR21AI126583 · NIAID · UNIVERSITY OF FLORIDA · PI AGBANDJE-MCKENNA, MAVIS · 2016 to 2017
$420k
NIAID NIH HHS R21 AI126583NIAID NIH HHS T32 AI007110NIH HHS 5R01GM109524-04NIH HHS 5T32AI007110-34
6 · The paper itself

Abstract

Adeno-associated viruses (AAVs) are being developed for gene delivery applications, with more than 100 ongoing clinical trials aimed at the treatment of monogenic diseases. In this study, the unique N-terminus of AAV capsid viral protein 1 (VP1u), containing a canonical group XIII PLA

Indexed as

Amino Acid SequenceAnimalsCalciumCapsid ProteinsDependovirusEnzyme ActivationHumansHydrogen-Ion ConcentrationIntrinsically Disordered ProteinsModels, MolecularPeptide HydrolasesProtease InhibitorsProtein ConformationProtein Interaction Domains and MotifsProteolysisSubstrate SpecificityCalciumCapsid ProteinsIntrinsically Disordered ProteinsPeptide HydrolasesProtease InhibitorsViral ProteinsAAVAdeno-associated virusphospholipase-A2PLA2protease

Identifiers

PMID31035643
PMCPMC6563295
OpenAlexW2942122928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.