Evidence map›Paper›PMID 31035617›Full record

ArticleNutrients2019

Combination of

Sing-Chung Li, Wei-Fang Hsu, Jung-Su Chang, Chun-Kuang Shih

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Nutrients · 2025
    Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Review
  9. Article
  10. Preventive Effect ofNutrients · 2026
    Article
  11. Review
  12. Potential mechanisms ofFrontiers in microbiology · 2026
    Review
  13. Frontiers in microbiology · 2026
    Article
  14. Article
  15. Modulating the microbiome as an approach to anticancer drug development.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Application and Challenges of Using ProbioticDiseases (Basel, Switzerland) · 2025
    Review
  17. Article
  18. Review
  19. Review
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sing-Chung LiSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan. sinchung@tmu.edu.tw.ORCID 0000-0003-4244-7911
Wei-Fang HsuSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan. greg_hsu@hotmail.com.
Jung-Su ChangSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan. susanchang@tmu.edu.tw.ORCID 0000-0001-8608-9349
Chun-Kuang ShihSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan. ckshih@tmu.edu.tw.ORCID 0000-0003-2545-911X
Taipei Medical University · TW

Funding

Ministry of Science and Technology, Taiwan NSC102-2313-B-038-006, MOST103-2313-B-038-004 & MOST104-2320-B-038-024
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is an emerging health problem associated with the dysregulation of the intestinal immune system and microbiome. Probiotics are able to reduce inflammatory responses in intestinal epithelial cells (IECs). However, entire signaling pathways and the interaction between different probiotics have not been well-documented. This study was designed to investigate the anti-inflammatory effects and mechanisms of single and combined probiotics. HT-29 cells were induced by lipopolysaccharide (LPS) and tumor necrosis factor (TNF)-α, treated with

Indexed as

Bifidobacterium animalisCytokinesGene Expression RegulationHT29 CellsHumansInflammationLactobacillus acidophilusLipopolysaccharidesTumor Necrosis Factor-alphaCytokinesLipopolysaccharidesTumor Necrosis Factor-alphaBifidobacterium animalis subsp. lactisinflammationintestinal epithelial cellsLactobacillus acidophilusprobiotics

Identifiers

PMID31035617
PMCPMC6566532
OpenAlexW2941558258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.