Evidence map›Paper›PMID 31035595›Full record

ReviewPharmaceutics2019

Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery.

Fedora Grande, Giuseppina Ioele, Maria Antonietta Occhiuzzi, Michele De Luca, Elisabetta Mazzotta, Gaetano Ragno, Antonio Garofalo, Rita Muzzalupo

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Novel Antiretroviral Therapeutic Strategies for HIV.Molecules (Basel, Switzerland) · 2021
    Review
  5. Article
  6. Nanosystems Applied to HIV Infection: Prevention and Treatments.International journal of molecular sciences · 2020
    Review
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fedora GrandeDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy. fedora.grande@unical.it.ORCID 0000-0002-6154-4330
Giuseppina IoeleDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy. giuseppina.ioele@unical.it.
Maria Antonietta OcchiuzziDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy. mariaantonietta.occhiuzzi@unical.it.
Michele De LucaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy. michele.deluca@unical.it.ORCID 0000-0001-9036-1595
Elisabetta MazzottaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy. mazzotta-elisabetta@libero.it.
Gaetano RagnoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy. gaetano.ragno@unical.it.ORCID 0000-0002-0510-3418
Antonio GarofaloDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy. antonio.garofalo@unical.it.
Rita MuzzalupoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Rende (CS), Italy. rita.muzzalupo@unical.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An in-depth analysis of nanotechnology applications for the improvement of solubility, distribution, bioavailability and stability of reverse transcriptase inhibitors is reported. Current clinically used nucleoside and non-nucleoside agents, included in combination therapies, were examined in the present survey, as drugs belonging to these classes are the major component of highly active antiretroviral treatments. The inclusion of such agents into supramolecular vesicular systems, such as liposomes, niosomes and lipid solid NPs, overcomes several drawbacks related to the action of these drugs, including drug instability and unfavorable pharmacokinetics. Overall results reported in the literature show that the performances of these drugs could be significantly improved by inclusion into nanosystems.

Indexed as

antiretroviralsdrug degradationdrug protectionHIVnanoformulations

Identifiers

PMID31035595
PMCPMC6572254

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.