Evidence map›Paper›PMID 31035583›Full record

ArticleJournal of clinical medicine2019

The Beneficial Effect of Acute Exercise on Motor Memory Consolidation is Modulated by Dopaminergic Gene Profile.

Lasse Christiansen, Richard Thomas, Mikkel M Beck, Jessica Pingel, Jeppe D Andersen, Cameron S Mang, Mads A J Madsen, Marc Roig, Jesper Lundbye-Jensen

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Trial
  3. Article
  4. Article
  5. Exercise and Cognitive Function.Journal of clinical medicine · 2019
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lasse ChristiansenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark. lassech@nexs.ku.dk.
Richard ThomasDepartment of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark. rith@teamdanmark.dk.
Mikkel M BeckDepartment of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark. mib@nexs.ku.dk.ORCID 0000-0002-8006-2580
Jessica PingelDepartment of Neuroscience, University of Copenhagen, 2200 Copenhagen, Denmark. jessica.pingel@gmail.com.
Jeppe D AndersenDepartment of Forensic Medicine, University of Copenhagen, 2200 Copenhagen, Denmark. jeppe.dyrberg.andersen@sund.ku.dk.
Cameron S MangFaculty of Kinesiology and Health Studies, University of Regina, Regina, SA S4S 0A2, Canada. Cameron.Mang@uregina.ca.ORCID 0000-0002-3376-5355
Mads A J MadsenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark. madsjm@drcmr.dk.
Marc RoigSchool of Physical and Occupational Therapy, McGill University, Montreal, QC H3G 1Y5, Canada. marc.roigpull@mcgill.ca.ORCID 0000-0002-1016-467X
Jesper Lundbye-JensenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark. jlundbye@nexs.ku.dk.ORCID 0000-0003-3144-861X
University of Copenhagen · DKJewish Rehabilitation Hospital · CAUniversity of Regina · CA

Funding

Nordea-fonden 02-2011-4360Sundhed og Sygdom, Det Frie Forskningsråd 4183-00462B
6 · The paper itself

Abstract

When aerobic exercise is performed following skilled motor practice, it can enhance motor memory consolidation. Previous studies have suggested that dopamine may play a role in motor memory consolidation, but whether it is involved in the exercise effects on consolidation is unknown. Hence, we aimed to investigate the influence of dopaminergic pathways on the exercise-induced modulation of motor memory consolidation. We compared the effect of acute exercise on motor memory consolidation between the genotypes that are known to affect dopaminergic transmission and learning. By combining cluster analyses and fitting linear models with and without included polymorphisms, we provide preliminary evidence that exercise benefits the carriers of alleles that are associated with low synaptic dopamine content. In line with previous reports, our findings implicate dopamine as a modulator of the exercise-induced effects on motor memory consolidation, and suggest exercise as a potential clinical tool to counteract low endogenous dopamine bioavailability. Further experiments are needed to establish causal relations.

Indexed as

consolidationdopaminedopamine receptorgeneticsmotor learningphysical activitysingle-nucleotide polymorphisms

Identifiers

PMID31035583
PMCPMC6572639
OpenAlexW2940631805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.