Evidence map›Paper›PMID 31035493›Full record

ArticleNutrients2019

Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS After a Lifestyle Intervention.

Lydia Morell-Azanza, Ana Ojeda-Rodríguez, Johanna Giuranna, Mª Cristina Azcona-SanJulián, Johannes Hebebrand, Amelia Marti, Anke Hinney

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lydia Morell-AzanzaDepartment of Nutrition, Food Sciences and Physiology, University of Navarra, c/Irunlarrea, 1. 31008 Pamplona, Spain. lmorell.1@alumni.unav.es.
Ana Ojeda-RodríguezDepartment of Nutrition, Food Sciences and Physiology, University of Navarra, c/Irunlarrea, 1. 31008 Pamplona, Spain. aojeda.5@alumni.unav.es.
Johanna GiurannaDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, D-45147, Essen,Germany. johanna.giuranna@uni-due.de.
Mª Cristina Azcona-SanJuliánIdiSNA, Instituto de Investigación Sanitaria de Navarra, c/Irunlarrea, 3. 31008, Pamplona , Spain. cazcona@unav.es.
Johannes HebebrandDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, D-45147, Essen,Germany. johannes.hebebrand@uni-duisburg-essen.de.
Amelia MartiDepartment of Nutrition, Food Sciences and Physiology, University of Navarra, c/Irunlarrea, 1. 31008 Pamplona, Spain. amarti@unav.es.
Anke HinneyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, D-45147, Essen,Germany. anke.hinney@uni-due.de.
Navarre Institute of Health Research · ESUniversity of Duisburg-Essen · DEInstituto de Salud Carlos III · ES

Funding

AEP ORDESABMBF 01GS0820Deutsche Forschungsgemeinschaft DFG; HI 865/2-1Merck Foundation -
6 · The paper itself

Abstract

Mutations leading to a reduced function of the melanocortin-4 receptor (MC4R) exert a major gene effect on extreme obesity. Recently it was shown that the bone derived hormone lipocalin 2 (LCN2) binds to the MC4R and activates a MC4R dependent anorexigenic pathway. We identified mutations in both genes and screened the effects of

Indexed as

Genetic VariationAdolescentBody Mass IndexChildFeeding BehaviorFemaleHumansLife StyleLipocalin-2MaleObesity, AbdominalPediatric ObesityReceptor, Melanocortin, Type 4SpainLipocalin-2Receptor, Melanocortin, Type 4childhood obesity, CEBQ, eating behavior and Ile251Leu

Identifiers

PMID31035493
PMCPMC6566731
OpenAlexW2942004032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.