Evidence map›Paper›PMID 31035469›Full record

Trial reportNutrients2019

Effects of a Novel Nutraceutical Combination (Aquilea Colesterol

Mònica Domenech, Rosa Casas, Ana Maria Ruiz-León, Javier Sobrino, Emilio Ros, Ramon Estruch

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mònica DomenechDepartment of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. mdomen@clinic.cat.
Rosa CasasDepartment of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. rcasas1@clinic.cat.ORCID 0000-0002-0211-9166
Ana Maria Ruiz-LeónDepartment of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. amruiz@clinic.cat.
Javier SobrinoDepartment of Internal Medicine, Fundació Hospital Esperit Sant, University of Barcelona, 08923 Barcelona, Spain. jsobrino@fhes.cat.ORCID 0000-0001-7438-4981
Emilio RosCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain. eros@clinic.ub.es.ORCID 0000-0002-2573-1294
Ramon EstruchDepartment of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain. restruch@clinic.cat.ORCID 0000-0003-1260-4445
Instituto de Salud Carlos III · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESUniversitat de Barcelona · ES

Funding

Uriach Laboratories, Spain 01/2016
6 · The paper itself

Abstract

backgroundCholesterol-lowering nutraceuticals are useful in the management of moderate hypercholesterolemia.

methodsIn a parallel-group, randomized, placebo-controlled double-blind trial we evaluated the effects on plasma total cholesterol, low-density lipoprotein cholesterol (LDL-c), and inflammatory biomarkers of a nutraceutical combination (Aquilea Colesterol

results13 men and 27 women (mean age 61.8 years) completed the trial; 20 participants received the nutraceutical and 20 received placebo. No adverse effects were noted. Compared to placebo, at one and three months the nutraceutical reduced total cholesterol by 11.4% and 14.1%, LDL-c by 19.8% and 19.7%, and apolipoprotein B by 12.4% and 13.5%, respectively (

conclusionThe nutraceutical Aquilea Colesterol

Indexed as

Dietary SupplementsAgedBiomarkersCardiovascular DiseasesDrug CombinationsFemaleHumansInflammationLipidsMaleMiddle AgedBiomarkersDrug CombinationsLipidsAquilea ColesterolC-reactive proteinhydroxytyrosolhypercholesterolemianutraceuticalsphytosterolsred yeast ricevitamin E

Identifiers

PMID31035469
PMCPMC6566177
OpenAlexW2941563071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.