Evidence map›Paper›PMID 31035445›Full record

ReviewInternational journal of molecular sciences2019

Application of Acyzol in the Context of Zinc Deficiency and Perspectives.

Gjumrakch Aliev, Yi Li, Vladimir N Chubarev, Svetlana A Lebedeva, Lidiya N Parshina, Boris A Trofimov, Susanna S Sologova, Alfiya Makhmutova, Marco F Avila-Rodriguez, Sergey G Klochkov and 2 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Alopecia Areata and Toxic Metals.Skin appendage disorders · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gjumrakch AlievDepartment of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. aliev03@gmail.com.ORCID 0000-0001-7373-3182
Yi LiDepartment of Biological and Health Sciences, Texas A&M University-Kingsville, TX 78363, USA. yi.li@tamuk.edu.
Vladimir N ChubarevDepartment of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. tchoubarov@mail.ru.
Svetlana A LebedevaDepartment of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. lebedeva502@yandex.ru.
Lidiya N ParshinaA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia. parshina@irioch.irk.ru.
Boris A TrofimovA.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia. boris_trofimov@irioch.irk.ru.
Susanna S SologovaDepartment of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. susanna.sologova@yandex.ru.
Alfiya MakhmutovaInstitute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia. alfiya@ipac.ac.ru.
Marco F Avila-RodriguezUniversidad del Tolima, Facultad de Ciencias de la Salud, Barrio Santa Helena, Ibagué 730006, Colombia. markos.avila@gmail.com.ORCID 0000-0003-4612-3236
Sergey G KlochkovInstitute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia. klochkov@ipac.ac.ru.ORCID 0000-0002-0299-9183
Pavel A Galenko-YaroshevskyDepartment of Pharmacology, Faculty of Pharmacy, Kuban State Medical University, 4 Sedin St., Krasnodar 350063, Russia. galenko.yarochevsky@gmail.com.
Vadim V TarasovDepartment of Pharmacology and Pharmacy, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya St., Moscow 119991, Russia. tarasov-v-v@mail.ru.

Funding

This work supported by Russian Academic Excellence project "5-100" for the Sechenov University, Moscow, Russia. This research was partially also supported in part within the framework of the State Proposal 0090-2017-0018, (topics 48.8. and 48.9), and by t Academic Excellence project "5-100" for the Sechenov University, The framework of the State Proposal 0090-2017-0018, (topics 48.8. and 48.9), and by the project of RAS Program "Fundamental Research for Biomedical Technologies' (IPAC, RAS Chernogolovka, Mo
6 · The paper itself

Abstract

Zinc is one of the most important essential trace elements. It is involved in more than 300 enzyme systems and is an indispensable participant in many biochemical processes. Zinc deficiency causes a number of disorders in the human body, the main ones being the delay of growth and puberty, immune disorders, and cognitive dysfunctions. There are over two billion people in the world suffering from zinc deficiency conditions. Acyzol, a zinc-containing medicine, developed as an antidote against carbon monoxide poisoning, demonstrates a wide range of pharmacological activities: Anti-inflammatory, reparative, detoxifying, immunomodulatory, bacteriostatic, hepatoprotective, adaptogenic, antioxidant, antihypoxic, and cardioprotective. The presence of zinc in the composition of Acyzol suggests the potential of the drug in the treatment and prevention of zinc deficiency conditions, such as Prasad's disease, immune system pathology, alopecia, allergodermatoses, prostate dysfunction, psoriasis, stomatitis, periodontitis, and delayed mental and physical development in children. Currently, the efficiency of Acyzol in the cases of zinc deficiency is shown in a large number of experimental studies. So, Acyzol can be used as a highly effective drug for pharmacologic therapy of a wide range of diseases and conditions and it opens up new perspectives in the treatment and prevention of zinc deficiency conditions.

Indexed as

AnimalsClinical Studies as TopicDrug Evaluation, PreclinicalHumansImidazolesMiceNutrition DisordersTrace ElementsTreatment OutcomeZincZinc AcetateImidazolesN-vinylimidazoleTrace ElementsZincZinc AcetateAcyzolcarbon monoxidepharmacological activityzinczinc deficiency conditions

Identifiers

PMID31035445
PMCPMC6539662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.