Evidence map›Paper›PMID 31034927›Full record

ReviewBiochimica et biophysica acta. Reviews on cancer2019

Nanoparticle-mediated targeted drug delivery for breast cancer treatment.

Piumi Y Liyanage, Sajini D Hettiarachchi, Yiqun Zhou, Allal Ouhtit, Elif S Seven, Cagri Y Oztan, Emrah Celik, Roger M Leblanc

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimica et biophysica acta. Reviews on cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Strategies for Targeting Mitochondria in the Treatment of Breast Cancer.ACS pharmacology & translational science · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Pulmonary fibrosis: from mechanisms to therapies.Journal of translational medicine · 2025
    Review
  18. Review
  19. Article
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Piumi Y LiyanageDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Sajini D HettiarachchiDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Yiqun ZhouDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Allal OuhtitDepartment of Biological & Environmental Sciences, College of Arts & Sciences, Qatar University, Doha, Qatar.
Elif S SevenDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA.
Cagri Y OztanDepartment of Aerospace and Mechanical Engineering, University of Miami, Coral Gables, FL 33146, USA.
Emrah CelikDepartment of Aerospace and Mechanical Engineering, University of Miami, Coral Gables, FL 33146, USA.
Roger M LeblancDepartment of Chemistry, University of Miami, Coral Gables, FL 33146, USA. Electronic address: rml@miami.edu.

Funding

Testing the therapeutic potential of carbon nanodots in bone mineralization diseasesR21AR072226 · NIAMS · UNIVERSITY OF RICHMOND · PI SKROMNE, ISAAC · 2017 to 2018
$316k
NIAMS NIH HHS R21 AR072226
6 · The paper itself

Abstract

Breast cancer (BC) is the most common malignancy in women worldwide, and one of the deadliest after lung cancer. Currently, standard methods for cancer therapy including BC are surgery followed by chemotherapy or radiotherapy. However, both chemotherapy and radiotherapy often fail to treat BC due to the side effects that these therapies incur in normal tissues and organs. In recent years, various nanoparticles (NPs) have been discovered and synthesized to be able to selectively target tumor cells without causing any harm to the healthy cells or organs. Therefore, NPs-mediated targeted drug delivery systems (DDS) have become a promising technique to treat BC. In addition to their selectivity to target tumor cells and reduce side effects, NPs have other unique properties which make them desirable for cancer treatment such as low toxicity, good compatibility, ease of preparation, high photoluminescence (PL) for bioimaging in vivo, and high loadability of drugs due to their tunable surface functionalities. In this study, we summarize with a critical analysis of the most recent therapeutic studies involving various NPs-mediated DDS as alternatives for the traditional treatment approaches for BC. It will shed light on the significance of NPs-mediated DDS and serve as a guide to seeking for the ideal methodology for future targeted drug delivery for an efficient BC treatment.

Indexed as

NanoparticlesAnimalsAntineoplastic AgentsBreast NeoplasmsDrug Delivery SystemsFemaleHumansMolecular Targeted TherapyAntineoplastic AgentsBioimagingBiomarkersBreast cancerDrug deliveryNanoparticles

Identifiers

PMID31034927
PMCPMC6549504

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.