Evidence map›Paper›PMID 31034816›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2019

3D bioprinting of vascular conduits for pediatric congenital heart repairs.

Wenhan Lee, Yi Hong, Guohao Dai

Abstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. 3D Bioprinting of Vascularized Tissues forFrontiers in bioengineering and biotechnology · 2021
    Review
  10. Article
  11. Article
  12. Current State of the Art in Ventricle Tissue Engineering.Frontiers in cardiovascular medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wenhan LeeDepartment of Bioengineering, Northeastern University, Boston, Massachusetts.
Yi HongDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas.
Guohao DaiDepartment of Bioengineering, Northeastern University, Boston, Massachusetts. Electronic address: g.dai@northeastern.edu.

Funding

Differentiating Embryonic Stem Cells Toward Arterial and Venous Endothelial Cells For Vascular RegenerationR01HL118245 · NHLBI · RENSSELAER POLYTECHNIC INSTITUTE · PI DAI, GUOHAO · 2013 to 2017
$1.9M
Elastic printable biomaterials for 3-D bioprinting of vascular conduitR21HD090680 · NICHD · NORTHEASTERN UNIVERSITY · PI DAI, GUOHAO · 2017 to 2018
$425k
Control Arterial-Venous Differentiation Using 3-Dimensional Cell Printing TechnolR21HL102773 · NHLBI · RENSSELAER POLYTECHNIC INSTITUTE · PI DAI, GUOHAO · 2010 to 2011
$384k
NHLBI NIH HHS R01 HL118245NHLBI NIH HHS R21 HL102773NICHD NIH HHS R21 HD090680
6 · The paper itself

Abstract

In children with congenital heart defects, surgical correction often involves the use of valves, patches or vascular conduits to establish anatomic continuity. Due to the differences between the pediatric and adult populations, tissue reconstruction in pediatric patients requires a substantially different approach from those in adults. Cardiovascular anatomy of children with congenital heart defect vary, which requires tailored surgical operations for each patient. Since grafts used in these palliative surgeries are sensitive to the local hemodynamic environments, their geometries need to be precisely designed to ensure long-term performance. Tissue engineered vascular grafts (TEVGs) have made tremendous progress over the past decade, but it remains difficult to fabricate patient- and operation-specific vascular grafts. This review summarizes historical milestones of TEVG development for repairing pediatric congenital defects and current clinical outcomes. We also highlight ongoing works on 3D bioprinting of TEVGs with complex geometries and address the current limitations of each technique. Although 3D bioprinted vascular grafts with appropriate functions are yet to be developed, some of the current researches are promising to create better patient specific tissue engineered vascular grafts in the future.

Indexed as

BioprintingPrinting, Three-DimensionalTissue ScaffoldsChildHeart Defects, CongenitalHumansTissue Engineering

Identifiers

PMID31034816
PMCPMC6702035

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.