ArticleThe Plant journal : for cell and molecular biology2019
Under phosphate starvation conditions, Fe and Al trigger accumulation of the transcription factor STOP1 in the nucleus of Arabidopsis root cells.
Article in The Plant journal : for cell and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 107 citations in OpenAlex.
- Aluminum and iron interactions in commelina communis: additive chloroplast toxicity versus synergistic internal and rhizosphere detoxification.Protoplasma · 2026Article
- The fluorescence-activating and absorption-shifting tag (FAST), a versatile protein marker for live plant cell imaging.The Plant journal : for cell and molecular biology · 2026Article
- BRAHMA represses STOP1-NRT1.1 module to control plant rhizosphere alkalization and acid stress adaptation.Nature communications · 2026Article
- ALUMINUM-ACTIVATED MALATE TRANSPORTER 1 (ALMT1) partially acidifies the rhizosphere in Pi deficiency-induced inhibition of primary root growth.Plant signaling & behavior · 2025Article
- A novel SlSTOP1-SlHAK5-cytosolic pH feedback loop drives dual adaptation to proton and aluminum toxicity in tomato.Horticulture research · 2025Article
- Genome-Wide Identification and Expression Analysis of Mitochondrial Dicarboxylate Carriers (DICs) in Medicago Under Aluminum Stress.Plants (Basel, Switzerland) · 2025Article
- CPK28-mediated CaNature communications · 2025Article
- Aluminum resistance in plants: A critical review focusing on STOP1.Plant communications · 2025Review
- Phosphate promotes Arabidopsis root skewing and circumnutation through reorganisation of the microtubule cytoskeleton.The New phytologist · 2024Article
- Evolution of phosphate scouting in the terrestrial biosphere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- The Role of Low-Molecular-Weight Organic Acids in Metal Homeostasis in Plants.International journal of molecular sciences · 2024Review
- Commonalities and Specificities in Wheat (International journal of molecular sciences · 2024Article
- Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants.International journal of molecular sciences · 2024Review
- Signaling function of NHPlanta · 2024Article
- The Phosphorus-Iron Nexus: Decoding the Nutrients Interaction in Soil and Plant.International journal of molecular sciences · 2024Review
- Soil and Mineral Nutrients in Plant Health: A Prospective Study of Iron and Phosphorus in the Growth and Development of Plants.Current issues in molecular biology · 2024Review
- Recent advances in research on phosphate starvation signaling in plants.Journal of plant research · 2024Review
- Sensing the toxic aluminum cations in acidic soils.Cell research · 2024Article
- Dissecting the Roles of Phosphorus Use Efficiency, Organic Acid Anions, and Aluminum-Responsive Genes under Aluminum Toxicity and Phosphorus Deficiency in Ryegrass Plants.Plants (Basel, Switzerland) · 2024Article
- Calcium signaling-mediated transcriptional reprogramming during abiotic stress response in plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Low-phosphate (Pi) conditions are known to repress primary root growth of Arabidopsis at low pH and in an Fe-dependent manner. This growth arrest requires accumulation of the transcription factor STOP1 in the nucleus, where it activates the transcription of the malate transporter gene ALMT1; exuded malate is suspected to interact with extracellular Fe to inhibit root growth. In addition, ALS3 - an ABC-like transporter identified for its role in tolerance to toxic Al - represses nuclear accumulation of STOP1 and the expression of ALMT1. Until now it was unclear whether Pi deficiency itself or Fe activates the accumulation of STOP1 in the nucleus. Here, by using different growth media to dissociate the effects of Fe from Pi deficiency itself, we demonstrate that Fe is sufficient to trigger the accumulation of STOP1 in the nucleus, which, in turn, activates the expression of ALMT1. We also show that a low pH is necessary to stimulate the Fe-dependent accumulation of nuclear STOP1. Furthermore, pharmacological experiments indicate that Fe inhibits proteasomal degradation of STOP1. We also show that Al acts like Fe for nuclear accumulation of STOP1 and ALMT1 expression, and that the overaccumulation of STOP1 in the nucleus of the als3 mutant grown in low-Pi conditions could be abolished by Fe deficiency. Altogether, our results indicate that, under low-Pi conditions, Fe
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