ArticleAlcoholism, clinical and experimental research2019
Sex Differences in Ethanol Reward Seeking Under Conflict in Mice.
Article in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Ovarian Hormones and Addictive Behaviour Vulnerability: Insights From Preclinical Studies.Addiction biology · 2025Pooled it
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- Chemogenetic activation of medial prefrontal cortex projections to the nucleus accumbens shell suppresses cocaine-primed reinstatement in EcoHIV infected mice.Psychopharmacology · 2026Article
- Sex differences in low-dose ethanol effects on motivated behavior and limbic corticostriatal activity in mice.Alcohol, clinical & experimental research · 2026Article
- Chronic intermittent ethanol vapor exposure alters local c-Fos and functional connectivity patterns evoked by alcohol cues.Alcohol, clinical & experimental research · 2026Article
- Sex-Specific patterns of vulnerability to alcohol addiction-like behaviors in rats.Translational psychiatry · 2026Article
- dCA1 cells encode and update contextual place preference.Frontiers in systems neuroscience · 2026Article
- Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice.Alcohol (Fayetteville, N.Y.) · 2025Article
- Sex Differences in Low-dose Ethanol Effects on Motivated Behavior and Limbic Corticostriatal Activity.bioRxiv : the preprint server for biology · 2025Article
- Individual differences in punished alcohol self-administration are unaltered by alcohol vapor exposure.Alcohol (Fayetteville, N.Y.) · 2025Observational
- Examining the predictive validity of alcohol-seeking following punishment-imposed abstinence in mice.Alcohol, clinical & experimental research · 2025Article
- Corticotropin releasing hormone receptor 1 in the medial prefrontal cortex mediates aversion resistant alcohol intake.Psychopharmacology · 2024Article
- Sex differences in neuronal activation in the cortex and midbrain during quinine-adulterated alcohol intake.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation.Communications biology · 2024Article
- Different mechanisms underlie compulsive alcohol self-administration in male and female rats.Biology of sex differences · 2024Article
- Adolescent alcohol disrupts development of noradrenergic neurons in the nucleus of the tractus solitarius and enhances stress behaviors in adulthood in mice in a sex specific manner.Addiction neuroscience · 2023Article
- Removal of the ovaries suppresses ethanol drinking and promotes aversion-resistance in C57BL/6J female mice.Psychopharmacology · 2023Article
- Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation.Research square · 2023Article
- Chemogenetic Perturbation of the Posterior But Not Anterior Cerebellum Reduces Voluntary Ethanol Consumption.eNeuro · 2023Article
- The maladaptive alcohol self-administration task: An adapted novel model of alcohol seeking with negative consequences.Journal of the experimental analysis of behavior · 2023Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundAlcohol use disorders are characterized by inflexible alcohol seeking that occurs despite adverse consequences. Males and females are differentially sensitive to ethanol (EtOH) reward, but it is unclear whether sex differences in EtOH seeking under reward-aversion conflict are present.
methodsTo investigate sex differences in EtOH seeking under conflict, adult male and female C57BL/6J mice underwent chronic intermittent EtOH (CIE) exposure by vapor inhalation or served as air-exposed controls. After CIE, mice were trained in a modified EtOH conditioned place preference paradigm. During 3 conditioning sessions, 2 g/kg EtOH was administered prior to confinement in the "EtOH-paired" chamber. On alternating days, saline was injected prior to confinement in the "saline-paired" chamber. After conditioning, mice experienced a footshock in the EtOH-paired chamber. EtOH-seeking behavior was assessed before and after footshock.
resultsControl and CIE-exposed males reduced the time spent in and increased latency to enter the reward-paired chamber following footshock. Control females did not alter EtOH-seeking behavior following footshock. CIE-exposed females spent more time in the EtOH-paired chamber at baseline. However, following a footshock, CIE-exposed females significantly reduced the time spent in and increased latency to enter the EtOH-paired chamber.
conclusionsNondependent female mice exhibited aversion-resistant alcohol seeking to a greater degree than males. Chronic EtOH exposure did not impact EtOH seeking in males. In females, CIE enhanced EtOH seeking in the absence of conflict, but reduced EtOH seeking after an aversive experience. While these sex-specific effects of CIE are not present when reward seeking is assessed in the absence of an aversive experience, multiple factors may underlie the differences in reward seeking despite adverse consequences, including reward- and aversion-related learning and decision making under conflict. These data highlight the importance of considering sex as a variable influencing EtOH seeking and provide a greater understanding of how sex interacts with EtOH exposure to alter behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.