ArticleJournal of radiation research2019
Hyaluronate gel injection for rectum dose reduction in gynecologic high-dose-rate brachytherapy: initial Japanese experience.
Article in Journal of radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility of ReSpace™ Hydrogel to Establish a Stable Cervical-rectal Space
A Prospective, Multicenter, Randomized, Parallel-controlled, Superiority Clinical Study to Evaluate the Effect of ReSpace™ Hydrogel on Reducing Rectal Radiation Dose in Radiotherapy for Cervical Cancer
A Prospective, Multicenter, Exploratory Clinical Study to Evaluate the Long-term Benefit of Hydrogel Spacer in Reducing Rectal Radiation Dose in Cervical Cancer Radiation Therapy.
Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Dosimetric impact of intrarectal gas removal by Foley catheter on image-guided adaptive brachytherapy in cervical cancer patients.Journal of contemporary brachytherapy · 2026Article
- Stabilised Hyaluronic Acid Gel Rectal Spacers in MRI-Guided Brachytherapy for Gynaecological Cancers: A Prospective Feasibility Study.Journal of medical radiation sciences · 2026Article
- A new hyaluronate gel spacer and injection technique for cervical cancer brachytherapy: a technical report.Journal of radiation research · 2025Article
- Hybrid inverse treatment planning optimization in gynecologic brachytherapy: Comparison with conventional method.Journal of contemporary brachytherapy · 2025Article
- Role of rectal spacers in gynecological cancer radiotherapy: reducing rectal dose and treatment-related toxicity.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025Review
- Protecting organs-at-risk in cancer therapies through temporary organ displacement: a comprehensive review.Oncology reviews · 2025Review
- Injectable bio-absorbable spacers in brachytherapy for gynecological cancers: A scoping review.Journal of contemporary brachytherapy · 2024Review
- A phase I clinical trial evaluating the application of hydrogel in reducing rectal dose during cervical cancer brachytherapy.Clinical and translational radiation oncology · 2024Article
- Article
- Daily Online Adaptive Radiation Therapy of Postoperative Endometrial and Cervical Cancer With PTV Margin Reduction to 5 mm: Dosimetric Outcomes, Acute Toxicity, and First Clinical Experience.Advances in radiation oncology · 2024Article
- Hyaluronic acid to manage radiotoxicities in gynecological cancer patients: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Effective timing of hyaluronate gel injection in image-guided adaptive brachytherapy for uterine cervical cancer: a proposal of the 'adjusted dose score'.Journal of radiation research · 2024Article
- A preliminary study on rectal dose reduction associated with hyaluronic acid implantation in brachytherapy for prostate cancer.Asian journal of urology · 2024Article
- Hydrogel spacer injection to the meso-sigmoid to protect the sigmoid colon in cervical cancer brachytherapy: A technical report.Journal of contemporary brachytherapy · 2023Article
- Article
- MucoUp® as a spacer in brachytherapy for uterine cervical cancer: A first-in-human experience.Clinical and translational radiation oncology · 2023Article
- Efficacy of injecting hybrid cooperative complexes of hyaluronic acid for the treatment of vulvar lichen sclerosus: A preliminary study.Journal of cosmetic dermatology · 2023Article
- SpaceOAR hydrogel spacer in interstitial brachytherapy for intrapelvic recurrent endometrial cancer.BJR case reports · 2022Article
- Now is it time to implement spacers in cervical cancer brachytherapy?Journal of radiation research · 2022Article
- An Asian multi-national multi-institutional retrospective study comparing intracavitary versus the hybrid of intracavitary and interstitial brachytherapy for locally advanced uterine cervical carcinoma.Journal of radiation research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perirectal hyaluronate gel injection (HGI) appears to be a promising technique for healthy tissue dose sparing in pelvic radiotherapy. In this analysis, we report our initial experience of HGI in gynecologic brachytherapy, focusing on its safety and effectiveness for dose reduction to the rectum. Between July 2013 and May 2014, 36 patients received HGI for primary/salvage gynecologic brachytherapy. Dosimetric effect analysis was based on pre- and post-HGI computed tomography dataset registration with corresponding dose-volume histogram evaluation. The maximum dose to the most exposed 0.1 cm3 (D0.1cm3) and 2.0 cm3 (D2.0cm3) were used as index values for rectum and bladder dose evaluation. The dose indexes for target volume (TV) coverage were TV D90/V100. In all cases, HGI was well tolerated, with no acute or late adverse events documented at a median follow-up of 220 days (range, 18-1046 days). Rectum D2.0cm3 and D0.1cm3 were significantly decreased by HGI (P < 0.001 and P = 0.003, respectively), with no significant impact on dosimetric parameters of bladder and TV coverage. Factors correlating negatively with the dosimetric effect of HGI were an increasing number of interstitial catheters (P = 0.003) as well as Lcranial100% (P = 0.014) and Lcranial80% (P = 0.001) [i.e. the length from the anal verge to the most cranial point at which the 100% and 80% isodose lines, respectively, crossed the rectum]. The concept of HGI for gynecologic brachytherapy is plausible, and our initial experience indicates it to be an effective technique for rectal dose reduction in radiotherapy of intrapelvic tumours.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.