ArticleThe American journal of pathology1987
A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits.
Article in The American journal of pathology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Targeting SRC enhances differentiation and promotes multifaceted cell death mechanisms in recurrent group 3 medulloblastoma.Cell death & disease · 2026Article
- Inhibition of the MET Receptor Tyrosine Kinase as a Novel Therapeutic Strategy in Medulloblastoma.Translational oncology · 2010Article
- Effects of basic fibroblast growth factor on the differentiation, growth, and viability of a new human medulloblastoma cell line (UM-MB1).The American journal of pathology · 1997Article
- Primitive neuroectodermal tumor cell lines derived from a metastatic pediatric tumor.In vitro cellular & developmental biology. Animal · 1994Article
- Neuron-associated class III beta-tubulin, tau, and MAP2 in the D-283 Med cell line and in primary explants of human medulloblastoma.The Histochemical journal · 1994Article
- Experimental production of primitive neuroectodermal tumors and its relevance to human neuro-oncology.The American journal of pathology · 1994Review
- Characterisation of a new mouse monoclonal antibody (ONS-M21) reactive with both medulloblastomas and gliomas.British journal of cancer · 1993Article
- Co-expression of low molecular weight neurofilament protein and glial fibrillary acidic protein in established human glioma cell lines.The American journal of pathology · 1993Article
- In vitro radiosensitivity of human medulloblastoma cell lines.Journal of neuro-oncology · 1993Article
- Immunohistochemical characterization of primitive neuroectodermal tumors and their possible relationship to the stepwise ontogenetic development of the central nervous system. 2. Tumor studies.Acta neuropathologica · 1991Article
- Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Immunologic characterization of Ewing's sarcoma using mesenchymal and neural markers.The American journal of pathology · 1989Article
- Phosphate-dependent and independent neurofilament protein epitopes are expressed throughout the cell cycle in human medulloblastoma (D283 MED) cells.The American journal of pathology · 1989Article
- Neuroblastic differentiation potential of the human retinoblastoma cell lines Y-79 and WERI-Rb1 maintained in an organ culture system. An immunohistochemical, electron microscopic, and biochemical study.The American journal of pathology · 1989Article
- Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc.The American journal of pathology · 1988Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The majority of cells in a rapidly dividing human medulloblastoma cell line (D283 MED) are shown to express the two high-molecular-weight human neurofilament (NF) subunits, whereas a minority express the low-molecular-weight NF subunit. These three polypeptides are integral subunits of the intermediate filaments (IFs) found in normal neurons. Other cell type-specific IF proteins (keratin, desmin, and glial filament polypeptides) are not present in D283 MED cells. Further, the immunocytochemical, immunochemical and ultrastructural data suggest that the neurofilaments in these cells are abnormal, possibly because of a paucity of the low-molecular-weight NF subunit. This is the first human cell line derived from a central nervous system tumor that is capable of expressing all three NF triplet proteins. It is a unique model system for studies of normal and abnormal human NF metabolism as well as for probing the cell biology of medulloblastomas.
Indexed as
Identifiers
3103453PMC1899580W1528608994What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.