Evidence map›Paper›PMID 31034489›Full record

ArticlePloS one2019

Novel approach for the assessment of ovarian follicles infiltration in polymeric electrospun patterned scaffolds.

Nathalie Raffel, Ralf Dittrich, Tobias Bäuerle, Lisa Seyler, Amir Fattahi, Inge Hoffmann, Aldo Leal-Egaña, Matthias W Beckmann, Aldo R Boccaccini, Liliana Liverani

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Tailor-made 3DFrontiers in endocrinology · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Current radiopharmaceuticals · 2024
    Review
  11. Article
  12. [Fertility and fertility preservation in women].Dermatologie (Heidelberg, Germany) · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Bioengineering models of female reproduction.Bio-design and manufacturing · 2020
    Article
  19. Engineered reproductive tissues.Nature biomedical engineering · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nathalie RaffelDepartment of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nürnberg, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
Ralf DittrichDepartment of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nürnberg, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
Tobias BäuerleDepartment of Radiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Lisa SeylerDepartment of Radiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
Amir FattahiDepartment of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nürnberg, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.ORCID 0000-0002-5712-5336
Inge HoffmannDepartment of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nürnberg, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
Aldo Leal-EgañaInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
Matthias W BeckmannDepartment of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen-Nürnberg, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
Aldo R BoccacciniInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
Liliana LiveraniInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-4270-4861
Comprehensive Cancer Center Erlangen · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reproductive tissue engineering (REPROTEN) has been recently defined as the application of the tissue engineering approach targeting reproductive organs and several research works are focusing on this novel strategy. Being still an innovative field, most of the scaffold characterization techniques suitable for other tissue targets give inappropriate results, and there is the need to evaluate and investigate novel approaches. In particular the focus of this paper is the evaluation of the infiltration of ovarian follicles inside patterned electrospun scaffolds. Beyond the standard techniques, for the first time the use of magnetic resonance imaging (MRI) for this purpose is proposed and specific protocols for scaffold preparation are reported. Positive results in terms of evaluation of scaffolds incorporating follicles confirm this technique as highly effective for further applications in this field.

Indexed as

AnimalsFemaleGelatinMagnetic Resonance ImagingOvarian FolliclePolymersSus scrofaTissue EngineeringTissue ScaffoldsGelatinPolymers

Identifiers

PMID31034489
PMCPMC6488091
OpenAlexW2942714117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.