ArticlePLoS genetics2019
Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Developmental priming of adult proteostasis and longevity by NuA4 complex activity in early life.The EMBO journal · 2026Article
- Interplay between proteostasis pathways and innate immune responses inInfection and immunity · 2026Review
- Epigenetic Regulation of Root-Associated Microbiota: Mechanisms and Horticultural Applications.Plants (Basel, Switzerland) · 2026Review
- Review
- Transcriptomic and chromatin accessibility profiling unveils new regulators of heat hormesis in Caenorhabditis elegans.PLoS biology · 2026Article
- Cosmic silence and viral noise: transcriptomic crosstalk inFrontiers in microbiology · 2026Article
- The transcription factor SKN-1 drives lysosomal enlargement during aging to maintain function.PLoS biology · 2025Article
- Lactate promotes longevity through redox-driven lipid remodeling inbioRxiv : the preprint server for biology · 2025Article
- Neuromedin U Receptor NMUR3 Regulates Autophagy, Thereby Enhancing Thermal Tolerance inInternational journal of molecular sciences · 2025Article
- The Mgv1-Rlm1 axis orchestrates SAGA and SWI/SNF complexes at target promoters.Nucleic acids research · 2025Article
- Chromatin and epigenetics in aging biology.Genetics · 2025Review
- Mini review: Studying epigenomic alterations can shed light on coping and adaptive abilities during heat stress in monogastric livestock.Frontiers in genetics · 2025Review
- FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species.Nature communications · 2024Article
- Establishment and Maintenance of Heat-Stress Memory in Plants.International journal of molecular sciences · 2024Review
- Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin.Science advances · 2024Article
- To live or let die? Epigenetic adaptations to climate change-a review.Environmental epigenetics · 2024Review
- Molecular characterization and modulated expression of histone acetyltransferases during cold response of the tick Dermacentor silvarum (Acari: Ixodidae).Parasites & vectors · 2023Article
- Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans.Nature communications · 2023Article
- Chromatin: the old and young of it.Frontiers in molecular biosciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Early exposure to some mild stresses can slow down the aging process and extend lifespan, raising the question of how early life stress might impact the somatic health of aged animals. Here, we reveal that early life heat experience triggers the establishment of epigenetic memory in soma, which promotes long-lasting stress responses and longevity in C. elegans. Unlike lethal heat shock, mild heat activates a unique transcriptional program mimicking pathogen defense responses, characterized by the enhanced expression of innate immune and detoxification genes. Surprisingly, the expression of defense response genes persists long after heat exposure, conferring enhanced stress resistance even in aged animals. Further studies identify the histone acetyltransferase CBP-1 and the chromatin remodeling SWI/SNF complex as epigenetic modulators of the long-lasting defense responses. Histone acetylation is elevated by heat stress and maintained into agedness thereafter. Accordingly, histone acetylation levels were increased on the promoters of defense genes. Moreover, disruption of epigenetic memory abrogates the longevity response to early hormetic heat stress, indicating that long-lasting defense responses are crucial for the survival of aged animals. Together, our findings provide mechanistic insights into how temperature stress experienced in early life provides animals with lifetime health benefits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.