Evidence map›Paper›PMID 31034426›Full record

ArticleIEEE journal of biomedical and health informatics2019

Giving Voice to Vulnerable Children: Machine Learning Analysis of Speech Detects Anxiety and Depression in Early Childhood.

Ellen W McGinnis, Steven P Anderau, Jessica Hruschak, Reed D Gurchiek, Nestor L Lopez-Duran, Kate Fitzgerald, Katherine L Rosenblum, Maria Muzik, Ryan S McGinnis

Abstract read
In one paragraph

Article in IEEE journal of biomedical and health informatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Preschool Mood Disorders: A Review of the Literature from 2017 to 2024.Child and adolescent psychiatric clinics of North America · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Exploring the impact of type II diabetes mellitus on voice quality.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ellen W McGinnis
Steven P Anderau
Jessica Hruschak
Reed D Gurchiek
Nestor L Lopez-Duran
Kate Fitzgerald
Katherine L Rosenblum
Maria Muzik
Ryan S McGinnis

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Infant Stress Response: Effects of Maternal PTSD and Infant GenesK23MH080147 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUZIK, MARIA · 2008 to 2011
$717k
Neurobehavioral assessments of RDoC domains to detect preschool mood disordersR03MH102648 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FITZGERALD, KATE DIMOND, ROSENBLUM, KATHERINE · 2014 to 2015
$167k
NCATS NIH HHS UL1 TR000433NIMH NIH HHS K23 MH080147NIMH NIH HHS R03 MH102648
6 · The paper itself

Abstract

Childhood anxiety and depression often go undiagnosed. If left untreated these conditions, collectively known as internalizing disorders, are associated with long-term negative outcomes including substance abuse and increased risk for suicide. This paper presents a new approach for identifying young children with internalizing disorders using a 3-min speech task. We show that machine learning analysis of audio data from the task can be used to identify children with an internalizing disorder with 80% accuracy (54% sensitivity, 93% specificity). The speech features most discriminative of internalizing disorder are analyzed in detail, showing that affected children exhibit especially low-pitch voices, with repeatable speech inflections and content, and high-pitched response to surprising stimuli relative to controls. This new tool is shown to outperform clinical thresholds on parent-reported child symptoms, which identify children with an internalizing disorder with lower accuracy (67-77% versus 80%), and similar specificity (85-100% versus 93%), and sensitivity (0-58% versus 54%) in this sample. These results point toward the future use of this approach for screening children for internalizing disorders so that interventions can be deployed when they have the highest chance for long-term success.

Indexed as

Machine LearningAnxietyChildChild, PreschoolDepressionFemaleHumansMalePsychopathologySignal Processing, Computer-AssistedSpeech

Identifiers

PMID31034426
PMCPMC7484854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.