Evidence map›Paper›PMID 31034279›Full record

ArticleAmerican journal of respiratory and critical care medicine2019

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.

Camille Moore, Rachel Z Blumhagen, Ivana V Yang, Avram Walts, Julie Powers, Tarik Walker, Makenna Bishop, Pamela Russell, Brian Vestal, Jonathan Cardwell and 113 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. AAmerican journal of respiratory and critical care medicine · 2022
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  13. Annals of the American Thoracic Society · 2025
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  18. Emerging cell and molecular targets for treating mucus hypersecretion in asthma.Allergology international : official journal of the Japanese Society of Allergology · 2024
    Review
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  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

123 authors at 20 institutions in 16 countries.

Camille Moore1 National Jewish Health, Denver, Colorado.
Rachel Z Blumhagen1 National Jewish Health, Denver, Colorado.
Ivana V Yang3 Department of Medicine, and.
Avram Walts3 Department of Medicine, and.
Julie Powers3 Department of Medicine, and.
Tarik Walker3 Department of Medicine, and.
Makenna Bishop3 Department of Medicine, and.
Pamela Russell1 National Jewish Health, Denver, Colorado.
Brian Vestal1 National Jewish Health, Denver, Colorado.
Jonathan Cardwell3 Department of Medicine, and.
Cheryl R Markin4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Susan K Mathai3 Department of Medicine, and.
Marvin I Schwarz3 Department of Medicine, and.
Mark P Steele3 Department of Medicine, and.
Joyce Lee3 Department of Medicine, and.
Kevin K Brown1 National Jewish Health, Denver, Colorado.
James E Loyd4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
James D Crapo1 National Jewish Health, Denver, Colorado.
Edwin K Silverman5 Brigham and Women's Hospital, Harvard School of Medicine, Boston, Massachusetts.
Michael H Cho5 Brigham and Women's Hospital, Harvard School of Medicine, Boston, Massachusetts.
Judith A James6 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
Joel M Guthridge6 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.
Joy D Cogan4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Jonathan A Kropski4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Jeffrey J Swigris1 National Jewish Health, Denver, Colorado.
Carol Bair1 National Jewish Health, Denver, Colorado.
Dong Soon Kim7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Wonjun Ji7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Hocheol Kim7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jin Woo Song7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Lisa A Maier1 National Jewish Health, Denver, Colorado.
Karin A Pacheco1 National Jewish Health, Denver, Colorado.
Nikhil Hirani8 MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Azin S Poon9 Respiratory Medicine Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.
Feng Li8 MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
R Gisli Jenkins10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
Rebecca Braybrooke10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
Gauri Saini10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
Toby M Maher11 Royal Brompton Hospital and Imperial College, London, United Kingdom.
Philip L Molyneaux11 Royal Brompton Hospital and Imperial College, London, United Kingdom.
Peter Saunders11 Royal Brompton Hospital and Imperial College, London, United Kingdom.
Yingze Zhang12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania.
Kevin F Gibson12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania.
Daniel J Kass12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania.
Mauricio Rojas12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania.
John Sembrat12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania.
Paul J Wolters13 Department of Medicine, University of California, San Francisco, San Francisco, California.
Harold R Collard13 Department of Medicine, University of California, San Francisco, San Francisco, California.
John S Sundy14 Gilead Sciences, Foster City, California.
Thomas O'Riordan14 Gilead Sciences, Foster City, California.
Mary E Strek15 Department of Medicine, University of Chicago, Chicago, Illinois.
Imre Noth16 Department of Medicine, University of Virginia, Charlottesville, Virginia.
Shwu-Fan Ma16 Department of Medicine, University of Virginia, Charlottesville, Virginia.
Mary K Porteous17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Maryl E Kreider17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Namrata B Patel17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Yoshikazu Inoue18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.ORCID 0000-0003-3994-874X
Masaki Hirose18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.
Toru Arai18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.
Shinobu Akagawa19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Oliver Eickelberg3 Department of Medicine, and.ORCID 0000-0001-7170-0360
Isis Enlil Fernandez20 Helmholtz Zentrum München, Neuherberg, Germany.
Jürgen Behr21 University Hospital Munich, Munich, Germany.
Nesrin Mogulkoc22 Department of Pulmonology, Ege University Hospital, Bornova, Izmir, Turkey.
Tamera J Corte23 Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia.
Ian Glaspole24 Alfred Hospital and Monash University, Melbourne, Australia.
Sara Tomassetti25 Pulmonary Medicine, GB Morgagni Hospital, Forlì, Italy.
Claudia Ravaglia26 Department of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy.
Venerino Poletti26 Department of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy.
Bruno Crestani27 Université Paris Diderot and Hôpital Bichat, Paris, France.
Raphael Borie27 Université Paris Diderot and Hôpital Bichat, Paris, France.
Caroline Kannengiesser27 Université Paris Diderot and Hôpital Bichat, Paris, France.
Helen Parfrey28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Christine Fiddler28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Doris Rassl28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Maria Molina-Molina29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain.
Carlos Machahua29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain.
Ana Montes Worboys29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain.
Gunnar Gudmundsson30 National University Hospital of Iceland, University of Iceland, Reykjavik, Iceland.
Helgi J Isaksson30 National University Hospital of Iceland, University of Iceland, Reykjavik, Iceland.
David J Lederer31 Department of Medicine, Columbia University Irving Medical Center, New York, New York.ORCID 0000-0001-5258-0228
Anna J Podolanczuk31 Department of Medicine, Columbia University Irving Medical Center, New York, New York.
Sydney B Montesi32 Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Elisabeth Bendstrup33 Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
Vivi Danchel33 Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
Moises Selman34 Instituto Nacional de Enfermedades Respiratorias "Ismael Cosio Villegas," México City, México.
Annie Pardo35 Universidad Nacional Autónoma de México, México City, México.
Michael T Henry36 Cork University Hospital and University College Cork, Cork, Ireland.
Michael P Keane37 St. Vincent's University Hospital, Dublin, Ireland.
Peter Doran37 St. Vincent's University Hospital, Dublin, Ireland.
Martina Vašáková39 Department of Respiratory Medicine, First Faculty of Medicine Charles University and Thomayer Hospital, Prague, Czech Republic.
Martina Sterclova39 Department of Respiratory Medicine, First Faculty of Medicine Charles University and Thomayer Hospital, Prague, Czech Republic.
Christopher J Ryerson40 University of British Columbia, Vancouver, Canada.
Pearce G Wilcox40 University of British Columbia, Vancouver, Canada.
Tsukasa Okamoto3 Department of Medicine, and.
Haruhiko Furusawa3 Department of Medicine, and.
Yasunari Miyazaki41 Tokyo Medical and Dental University, Tokyo, Japan.
Geoffrey Laurent42 Institute for Respiratory Health and.
Svetlana Baltic42 Institute for Respiratory Health and.
Cecilia Prele42 Institute for Respiratory Health and.
Yuben Moodley42 Institute for Respiratory Health and.
Barry S Shea44 Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Ken Ohta19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Maho Suzukawa19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Osamu Narumoto19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Steven D Nathan45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia.
Drew C Venuto45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia.
Merte L Woldehanna45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia.
Nurdan Kokturk46 Department of Pulmonary Medicine, Gazi University School of Medicine, Ankara, Turkey.
Joao A de Andrade47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Tracy Luckhardt47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Tejaswini Kulkarni47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Francesco Bonella48 Ruhrlandklinik, University Hospital, University of Duisburg-Essen, Essen, Germany.
Seamus C Donnelly49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland.
Aoife McElroy49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland.
Michelle E Armstong49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland.
Alvaro Aranda50 CardioPulmonary Reserach Center, Alliance Pulmonary Group, Guaynabo, Puerto Rico.
Roberto G Carbone51 Department of Internal Medicine, University of Genoa, Genoa, Italy.
Francesco Puppo51 Department of Internal Medicine, University of Genoa, Genoa, Italy.
Kenneth B Beckman52 Biomedical Genomics Center, University of Minnesota; Minneapolis, Minnesota; and.
Deborah A Nickerson53 Northwest Genomics Center, University of Washington, Seattle, Washington.
Tasha E Fingerlin1 National Jewish Health, Denver, Colorado.
David A Schwartz1 National Jewish Health, Denver, Colorado.
National Jewish Health · USColorado School of Public Health · USUniversity of Pittsburgh · USTokyo National Hospital · JPUlsan College · KRVanderbilt University · USBellvitge University Hospital · ESCambridge University Hospitals NHS Foundation Trust · GBDélégation Paris 7 · FRInova Fairfax Hospital · USNHO Kinki Chuo Chest Medical Center · JPRoyal Brompton Hospital · GBTokyo Medical and Dental University · JPTrinity College Dublin · IEUniversity of Nottingham · GBUniversity of Pennsylvania · USAarhus University Hospital · DKBrigham and Women's Hospital · USCharles University · CZColumbia University Irving Medical Center · US

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI PAUL G SPICER · 2013 to 2026
$68.2M
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Mechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLACKWELL, TIMOTHY S. · 2010 to 2020
$21.6M
MULTIDISCIPLINARY RESPIRATORY DISEASES RESEARCH TRAININGT32HL007085 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELLEN L BURNHAM, LISA A MAIER · 1985 to 2026
$21.6M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)R01HL097163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E., SCHWARTZ, DAVID ALBERT · 2009 to 2018
$16.4M
Oklahoma Rheumatic Disease Research Cores Center (Overall Application)P30AR073750 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI JUDITH A JAMES · 2018 to 2026
$8.5M
SNP Confirmation and High Throughput Genotyping CoreP30AR053483 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GUTHRIDGE, JOEL MARVIN · 2007 to 2017
$6.7M
Pre-Clinical Studies to Identify SLE Therapeutic TargetsU19AI082714 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GAFFNEY, PATRICK M · 2009 to 2018
$6.2M
MUC5B, a novel therapeutic target for Idiopathic Pulmonary Fibrosis (IPF)UH3HL123442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SCHWARTZ, DAVID ALBERT · 2016 to 2018
$4.8M
Architectural structure and regulation of TOLLIP in IPFR01HL130796 · NHLBI · UNIVERSITY OF VIRGINIA · PI NOTH, IMRE · 2016 to 2019
$3.1M
BLRD VA I01 BX002378Department of Health RP-2017-08-ST2-014Medical Research Council MR/N005953/1NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K08 HL130595NHLBI NIH HHS P01 HL092870NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R01 HL130796NHLBI NIH HHS R33 HL120770NHLBI NIH HHS T32 HL007085NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS UH3 HL123442NIAID NIH HHS U19 AI082714NIAMS NIH HHS P30 AR053483NIAMS NIH HHS P30 AR073750NIGMS NIH HHS U54 GM104938
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ATP-Binding Cassette TransportersCase-Control StudiesCellular SenescenceDNA HelicasesExoribonucleasesFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGTPase-Activating ProteinsHigh-Throughput Nucleotide SequencingHost-Pathogen InteractionsHumansIdiopathic Pulmonary FibrosisLogistic ModelsMaleABCA3 protein, humanATP-Binding Cassette TransportersDNA HelicasesExoribonucleasesFAM13A protein, humanGTPase-Activating ProteinsMUC5B protein, humanMucin-5BPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated Protein CRNARTEL1 protein, humanSFTPA2 protein, humanSFTPC protein, humanTelomerasetelomerase RNATelomere-Binding ProteinsTERT protein, humanTINF2 protein, humandisease risk allelesgenetic variantsidiopathic pulmonary fibrosisrare variantstargeted resequencing

Identifiers

PMID31034279
PMCPMC6635791
OpenAlexW2943293482

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.