ArticleJournal of biophotonics2019
Capsule optoacoustic endoscopy for esophageal imaging.
Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- From lab design to clinical translation: photoacoustic endoscopy.Photoacoustics · 2026Review
- An ingestible light source for deep photoacoustic imaging.Photoacoustics · 2026Article
- Tethered optoacoustic and optical coherence tomography capsule endoscopy for label-free assessment of Barrett's oesophageal neoplasia.Nature biomedical engineering · 2026Article
- Compact photoacoustic endoscopy by measuring initial photoacoustic pressure using phase-shift interferometry.Photoacoustics · 2025Article
- A primer on current status and future opportunities of clinical optoacoustic imaging.Npj imaging · 2025Review
- In Vivo Assessment of Deep Vascular Patterns in Murine Colitis Using Optoacoustic Mesoscopic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Enhanced dual-mode imaging: Superior photoacoustic and ultrasound endoscopy in live pigs using a transparent ultrasound transducer.Science advances · 2024Article
- Recent Advances in Photoacoustic Imaging: Current Status and Future Perspectives.Micromachines · 2024Review
- Perspectives on endoscopic functional photoacoustic microscopy.Applied physics letters · 2024Article
- Ultrasound in Pediatric Inflammatory Bowel Disease-A Review of the State of the Art and Future Perspectives.Children (Basel, Switzerland) · 2024Review
- Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free In Vivo Assessment of Colitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Optical-resolution functional gastrointestinal photoacoustic endoscopy based on optical heterodyne detection of ultrasound.Nature communications · 2022Article
- Looking deep inside tissue with photoacoustic molecular probes: a review.Journal of biomedical optics · 2022Review
- Photoacoustic/Ultrasound Endoscopic Imaging Reconstruction Algorithm Based on the Approximate Gaussian Acoustic Field.Biosensors · 2022Article
- Intra-instrument channel workable, optical-resolution photoacoustic and ultrasonic mini-probe system for gastrointestinal endoscopy.Photoacoustics · 2022Article
- 360Photoacoustics · 2022Article
- Correlation of in vivo imaging to morphomolecular pathology in translational research: challenge accepted.EJNMMI research · 2021Article
- Advances in Endoscopic Photoacoustic Imaging.Photonics · 2021Article
- Ultra-broadband axicon transducer for optoacoustic endoscopy.Scientific reports · 2021Article
- Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging.Advances in experimental medicine and biology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Detection and monitoring of esophageal cancer severity require an imaging technique sensitive enough to detect early pathological changes in the esophagus and capable of analyzing the esophagus over 360 °in a non-invasive manner. Optoacoustic endoscopy (COE) has been shown to resolve superficial vascular structure of the esophageal lumen in rats and rabbits using catheter-type probes. Although these systems can work well in small animals, they are unsuitable for larger lumens with thicker walls as required for human esophageal screening, due to their lack of position stability along the full organ circumference, sub-optimal acoustic coupling and limited signal-to-noise ratio (SNR). In this work, we introduce a novel capsule COE system that provides high-quality 360° images of the entire lumen, specifically designed for typical dimensions of human esophagus. The pill-shaped encapsulated probe consists of a novel and highly sensitive ultrasound transducer fitted with an integrated miniature pre-amplifier, which increases SNR of 10 dB by minimizing artifacts during signal transmission compared to the configuration without the preamplifier. The scanner rotates helically around the central axis of the probe to capture three-dimensional images with uniform quality. We demonstrate for the first time ex vivo volumetric vascular network images to a depth of 2 mm in swine esophageal lining using COE. Vascular information can be resolved within the mucosa and submucosa layers as confirmed by histology of samples stained with hematoxylin and eosin and with antibody against vascular marker CD31. COE creates new opportunities for optoacoustic screening of esophageal cancer in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.