Evidence map›Paper›PMID 31034033›Full record

Trial reportThe Journal of nutrition2019

Maternal and Infant Lipid-Based Nutritional Supplementation Increases Height of Ghanaian Children at 4-6 Years Only if the Mother Was Not Overweight Before Conception.

Sika M Kumordzie, Seth Adu-Afarwuah, Mary Arimond, Rebecca R Young, Theodosia Adom, Rose Boatin, Maku E Ocansey, Harriet Okronipa, Elizabeth L Prado, Brietta M Oaks and 1 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00970866 (Efficacy of Lipid-based Nutrient Supplements), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00970866 nacompletednot on this map

Efficacy of Lipid-based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants

TypeinterventionalSponsorUniversity of California, DavisRan2009 to 2017Enrolled3,499ConditionsAnemia, Malnutrition, StuntingArmsIron and Folic Acid (IFA), Multiple Micronutrient (MMN) group, Lipid-based Nutrient Supplements (LNS) group
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Sika M KumordzieProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Ghana.
Mary ArimondProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Rebecca R YoungProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Theodosia AdomNutrition Research Centre, Radiological and Medical Sciences Research Institute, Ghana Atomic Energy Commission, Legon, Ghana.
Rose BoatinNutrition Research Centre, Radiological and Medical Sciences Research Institute, Ghana Atomic Energy Commission, Legon, Ghana.
Maku E OcanseyProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Harriet OkronipaProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Elizabeth L PradoProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Brietta M OaksProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
Kathryn G DeweyProgram in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.
University of California, Davis · USGhana Atomic Energy Commission · GHFamily Health International 360 · USUniversity of Ghana · GHUniversity of Rhode Island · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies have evaluated the long-term effects of nutritional supplementation during the first 1000 d of life. We previously reported that maternal and child lipid-based nutrient supplements (LNS) increased child length by 18 mo.

objectiveThe aim of this study was to examine the effects of LNS on later growth and body composition at 4-6 y of age.

designThis was a follow-up of children in the International Lipid-based Nutrient Supplements (iLiNS)-DYAD trial in Ghana. Women (n = 1320) at ≤20 weeks of gestation were randomly assigned to: 1) iron and folic acid during pregnancy and 200 mg calcium/d for 6 mo postpartum, 2) multiple micronutrients (1-2 RDA of 18 vitamins and minerals) during both periods, or 3) maternal LNS during both periods plus child LNS from 6 to 18 mo. At 4-6 y, we compared height, height-for-age z score (HAZ), and % body fat (deuterium dilution method) between the LNS group and the 2 non-LNS groups combined.

resultsData were available for 961 children (76.5% of live births). There were no significant differences between LNS compared with non-LNS groups in height [106.7 compared with 106.3 cm (mean difference, MD, 0.36; P = 0.226)], HAZ [-0.49 compared with -0.57 (MD = 0.08; P = 0.226)], stunting (< -2 SD) [6.5 compared with 6.3% (OR = 1.00; P = 0.993)], or % body fat [15.5 compared with 15.3% (MD = 0.16; P = 0.630)]. However, there was an interaction with maternal prepregnancy BMI (kg/m2) (P-interaction = 0.046 before correction for multiple testing): among children of women with BMI < 25 , LNS children were taller than non-LNS children (+1.1 cm, P = 0.017), whereas there was no difference among children of women with BMI ≥ 25 (+0.1 cm; P = 0.874).

conclusionsThere was no overall effect of LNS on height at 4-6 y in this cohort, which had a low stunting rate, but height was greater in the LNS group among children of nonoverweight/obese women. There was no adverse impact of LNS on body composition. This trial was registered at clinicaltrials.gov as NCT00970866.

Indexed as

Body Mass IndexDietary SupplementsGrowth DisordersPrenatal Nutritional Physiological PhenomenaAdipose TissueAdultBody CompositionBody HeightChildChild, PreschoolFemaleGhanaHumansInfantInfant, NewbornLipidsLipidsMicronutrientsbody compositionfollow-upgrowthlipid-based nutrient supplementsprenatal supplementation

Identifiers

PMID31034033
PMCPMC6499103
OpenAlexW2942800273

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.