Evidence map›Paper›PMID 31033913›Full record

ArticleThe Pediatric infectious disease journal2019

Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection.

Jane R Millar, Zodumo Mvo, Nomonde Bengu, Rowena Fillis, Ken Sprenger, Philippa C Matthews, Moherndran Archary, Thumbi Ndung'u, Emily Adland, Maria C Puertas and 3 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Pediatric infectious disease journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 5 countries.

Jane R MillarUmkhuseli Innovation and Research Management, Pietermaritzburg, South Africa.
Zodumo MvoUmkhuseli Innovation and Research Management, Pietermaritzburg, South Africa.
Nomonde BenguUmkhuseli Innovation and Research Management, Pietermaritzburg, South Africa.
Rowena FillisUmkhuseli Innovation and Research Management, Pietermaritzburg, South Africa.
Ken SprengerUmkhuseli Innovation and Research Management, Pietermaritzburg, South Africa.
Philippa C MatthewsDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Moherndran ArcharyDepartment of Paediatrics, University of KwaZulu-Natal, Durban, South Africa.
Thumbi Ndung'uRagon Institute of MGH, MIT and Havard, Cambridge, MA, USA.
Emily AdlandDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Maria C PuertasAIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain.
Javier Martinez-PicadoAIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain.
Philip GoulderDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Ucwaningo Lwabantwana Consortium Group
Umkhuseli Innovation and Research Management · ZAUniversity of KwaZulu-Natal · ZAUniversity of Oxford · GBInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESMax Planck Institute for Infection Biology · DE

Funding

Maximising Cure Potential in Paediatric HIV InfectionR01AI133673 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2017 to 2021
$1.4M
NIAID NIH HHS R01 AI133673Wellcome Trust 104748Wellcome Trust 107752
6 · The paper itself

Abstract

We present a case of an in utero HIV-infected child, who on day 1 of life had a positive whole blood total nucleic acid test but viral load <20 RNA copies/mL. Dried blood spot total nucleic acid testing was negative on day 1, 10 and at 3 months, while on ART prophylaxis then positive at 5 months after prophylaxis ended. Retrospective peripheral blood mononuclear cells HIV DNA testing from day 1 of life was positive, confirming in utero infection.

Indexed as

HIV-1Infectious Disease Transmission, VerticalAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChildFemaleHIV InfectionsHumansInfant, NewbornTreatment OutcomeViral Load

Identifiers

PMID31033913
PMCPMC7612888
OpenAlexW2943811732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.