Evidence map›Paper›PMID 31033823›Full record

SynthesisPlastic and reconstructive surgery2019

Unconventional Perfusion Flaps in the Experimental Setting: A Systematic Review and Meta-Analysis.

Diogo Casal, David Tanganho, Teresa Cunha, Eduarda Mota-Silva, Inês Iria, Diogo Pais, Paula Videira, José Videira-Castro, João Goyri-O'Neill

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Plastic and reconstructive surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Diogo CasalFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.
David TanganhoFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.
Teresa CunhaFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.
Eduarda Mota-SilvaFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.
Inês IriaFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.
Diogo PaisFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.
Paula VideiraFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.
José Videira-CastroFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.
João Goyri-O'NeillFrom the Plastic and Reconstructive Surgery Department and Burn Unit, Centro Hospitalar de Lisboa Central; the Anatomy Department, Nova Medical School; UCIBIO, Departamento de Ciências da Vida, and LIBPhys-Physics Department, Faculdade de Ciências e Tecnologias, Universidade NOVA de Lisboa; and Molecular Microbiology and Biotechnology Unit/Drug Discovery Area, Faculdade de Farmácia, Universidade de Lisboa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnconventional perfusion flaps offer multiple potential advantages compared with traditional flaps. Although there are numerous experimental articles on unconventional perfusion flaps, the multiple animal species involved, the myriad vascular constructions used, and the frequently conflicting data reported make synthesis of this information challenging. The main aim of this study was to perform a systematic review and meta-analysis of the literature on the experimental use of unconventional perfusion flaps, to identify the best experimental models proposed and to estimate their global survival rate.

methodsThe authors performed a systematic review and meta-analysis of all articles written in English, French, Italian, Spanish, and Portuguese on the experimental use of unconventional perfusion flaps and indexed to PubMed from 1981 until February 1, 2017.

resultsA total of 68 studies were found, corresponding to 86 optimized experimental models and 1073 unconventional perfusion flaps. The overall unconventional perfusion flap survival rate was 90.8 percent (95 percent CI, 86.9 to 93.6 percent; p < 0.001). The estimated proportion of experimental unconventional perfusion flaps presenting complete survival or nearly complete survival was 74.4 percent (95 percent CI, 62.1 to 83.7 percent; p < 0.001). The most commonly reported animal species in the literature were the rabbit (57.1 percent), the rat (26.4 percent), and the dog (14.3 percent). No significant differences were found in survival rates among these species, or among the diverse vascular patterns used.

conclusionThese data do not differ significantly from those reported regarding the use of unconventional perfusion flaps in human medicine, suggesting that rabbit, rat, and canine experimental unconventional perfusion flap models may adequately mimic the clinical application of unconventional perfusion flaps.

Indexed as

Graft SurvivalModels, AnimalAnimalsDogsPlastic Surgery ProceduresPostoperative ComplicationsRabbitsRatsSurgical FlapsTreatment Outcome

Identifiers

PMID31033823
PMCPMC6493691

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.