ArticleOrganic letters2019
Brønsted Acid-Catalyzed Formal [2 + 2 + 1] Annulation for the Modular Synthesis of Tetrahydroindoles and Tetrahydrocyclopenta[ b]pyrroles.
Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Diazacyclobutenes as Reactive Intermediates: The Cascade Cyclization of Thiolated Ene-ynes and Azodicarboxylates to Provide Tetrahydroindoles.The Journal of organic chemistry · 2025Article
- Recent advances in metal-free catalysts for the synthesis of N-heterocyclic frameworks focusing on 5- and 6-membered rings: a review.RSC advances · 2025Review
- Synthesis of 2,3-Disubstituted Pyrroles by Lewis Acid Promoted Cyclization ofTetrahedron letters · 2023Article
- Direct synthesis of pentasubstituted pyrroles and hexasubstituted pyrrolines from propargyl sulfonylamides and allenamides.Chemical science · 2021Article
- Recent Advancements in Pyrrole Synthesis.Synthesis · 2021Article
- Synthesis of functionalized tetrahydropyrans via cascade cycloaddition involving silyloxyallyl cation intermediates.Chemical communications (Cambridge, England) · 2020Article
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Authors and funding
4 authors.
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Abstract
An expedient synthesis of tetrahydroindoles and tetrahydrocyclopenta[ b]pyrroles, highlighted by Brønsted acid catalyzed formal [2 + 2 + 1] annulation reaction, is reported. Using three readily accessible reaction components, i.e., an electrophilic species in silyloxyallyl cations and two distinct nucleophiles in silylenol ethers and amines, our chemistry enables the assembly and functionalization of these biologically important N-heterocycles in a highly modular manner.
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