ArticleOrganic letters2019
Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions.
Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Diastereoselective synthesis of tetrahydroisoquinolines through the Pd-catalyzed post-Ugi transformations.RSC advances · 2026Article
- Copper-catalyzed one-pot synthesis of isoquinolinesRSC advances · 2026Article
- Recent Advances in Synthetic Isoquinoline-Based Derivatives in Drug Design.Molecules (Basel, Switzerland) · 2025Review
- One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline.Beilstein journal of organic chemistry · 2024Article
- Article
- Highly Stereoselective Ugi/Pictet-Spengler Sequence.The Journal of organic chemistry · 2022Article
- Isoquinolone-4-Carboxylic Acids by Ammonia-Ugi-4CR and Copper-Catalyzed Domino Reaction.The Journal of organic chemistry · 2021Article
- Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers.RSC medicinal chemistry · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The Pomeranz-Fritsch reaction and its Schlittler-Müller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde diethyl acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds, and benzo[ d]azepinone scaffolds, were synthesized in generally moderate to good yield. All our syntheses provide a short MCR-based sequence to novel or otherwise difficult to access scaffolds. Hence, we foresee multiple applications of these synthesis technologies.
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Registered trials
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