ArticleZoonoses and public health2019
First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats (Rattus norvegicus) from Great Britain.
Article in Zoonoses and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Rodent-borne pathogens as economic and zoonotic health threat to livestock farming: a review.One health (Amsterdam, Netherlands) · 2026Review
- Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact.Nature communications · 2026Review
- Zoonotic rat hepatitis E virus infection in pigs: farm prevalence and public health relevance.Porcine health management · 2025Article
- Substantial spillover burden of rat hepatitis E virus in humans.Nature communications · 2025Article
- Diversity of Hepatitis E Viruses in Rats in Yunnan Province and the Inner Mongolia Autonomous Region of China.Viruses · 2025Article
- National survey of the rat hepatitis E virus in rodents in Spain, 2022 to 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Article
- Detection of hepatitis E virus genotype 3 in an Algerian mouse (Mus spretus) in Portugal.Veterinary research communications · 2024Article
- Review
- Rat Hepatitis E Virus in Norway Rats, Ontario, Canada, 2018-2021.Emerging infectious diseases · 2023Article
- First Detection of Hepatitis E Virus (Viruses · 2023Article
- Comparison of viral communities in the blood, feces and various tissues of wild brown rats (Heliyon · 2023Article
- Detection of Hepatitis E Virus Genotype 3 in Feces of Capybaras (Hydrochoeris hydrochaeris) in Brazil.Viruses · 2023Article
- Article
- Infection dynamics and persistence of hepatitis E virus on pig farms - a review.Porcine health management · 2021Review
- Rat Hepatitis E Virus: Presence in Humans in South-Western France?Frontiers in medicine · 2021Article
- Review
- Review
- First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats (Rattus norvegicus) from Great Britain.Zoonoses and public health · 2019Article
- The Clinical Perspective on Hepatitis E.Viruses · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the United Kingdom, there has been an increase in the number of hepatitis E virus (HEV) infections in people annually since 2010. Most of these are thought to be indigenously acquired Orthohepevirus A genotype 3 (HEV G3), which has been linked to pork production and consumption. However, the dominant subgroup circulating in British pigs differs from that which is found in people; therefore, an alternative, potentially zoonotic, source is suspected as a possible cause of these infections. Rodents, brown rats (Rattus norvegicus) in particular, have been shown to carry HEV, both the swine HEV G3 genotype and Orthohepevirus C, genotype C1 (rat HEV). To investigate the prevalence of HEV in British rodents, liver tissue was taken from 307 rodents collected from pig farms (n = 12) and other locations (n = 10). The RNA from these samples was extracted and tested using a pan-HEV nested RT-PCR. Limited histopathology was also performed. In this study, 8/61 (13%, 95% CI, 5-21) of brown rat livers were positive for HEV RNA. Sequencing of amplicons demonstrated all infections to be rat HEV with 87%-92% nucleotide identity to other rat HEV sequences circulating within Europe and China (224 nt ORF-1). Lesions and necrosis were observed histologically in 2/3 samples examined. No rat HEV RNA was detected in any other species, and no HEV G3 RNA was detected in any rodent in this study. This is the first reported detection of rat HEV in Great Britain. A human case of rat HEV infection has recently been reported in Asia, suggesting that rat HEV could pose a risk to public health.
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