ArticleChemSusChem2019
A Ball-Milling-Enabled Reformatsky Reaction.
Article in ChemSusChem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The grinding route for synthesis of dihydropyrrolophenanthrolines and their conversion to dipyrrolophenanthrolines under reflux condition.Scientific reports · 2025Article
- Mechanochemical Strategies Applied to the Late-Stage Modifications of Pharmaceutically Active Compounds.Angewandte Chemie (International ed. in English) · 2025Review
- Mechanochemical Aerobic Activation of Metallic Copper for the Synthesis of 1,4-Allenynes.ChemSusChem · 2025Article
- Liquid-Assisted Grinding Enables Efficient Ni-Catalyzed, Mn-Mediated Denitrogenative Cross-Electrophile Coupling of Benzotriazinones with Benzyl Chlorides.Molecules (Basel, Switzerland) · 2025Article
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- Metal Activation Produces Different Reaction Environments for Intermediates during Oxidative Addition.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Mechanochemical synthesis of organoselenium compounds.Nature communications · 2024Article
- Mechanochemical protocol facilitates the generation of arylmanganese nucleophiles from unactivated manganese metal.Chemical science · 2023Article
- Mechanical Activation of Zero-Valent Metal Reductants for Nickel-Catalyzed Cross-Electrophile Coupling.ACS catalysis · 2022Article
- Article
- The Reformatsky analogous reaction for the synthesis of novel β-thioxoestersRSC advances · 2022Article
- Mechanochemical Organocatalysis: Do High Enantioselectivities Contradict What We Might Expect?ChemSusChem · 2022Review
- Complementarity of solution and solid state mechanochemical reaction conditions demonstrated by 1,2-debromination of tricyclic imides.Beilstein journal of organic chemistry · 2022Article
- Ball-Milling-Enabled Reactivity of Manganese Metal*.Angewandte Chemie (International ed. in English) · 2021Article
- Mechanoredox Chemistry as an Emerging Strategy in Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Mechanochemical Solvent-Free Catalytic C-H Methylation.Angewandte Chemie (International ed. in English) · 2021Article
- Reaction of Aldoximes with Sodium Chloride and Oxone under Ball-Milling Conditions.Molecules (Basel, Switzerland) · 2020Article
- N-Heterocyclic Carbene Acyl Anion Organocatalysis by Ball-Milling.ChemSusChem · 2020Article
- A Ball-Milling-Enabled Reformatsky Reaction.ChemSusChem · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
An operationally simple one-jar one-step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre-activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39-82 % yield) and is effective irrespective of the initial morphology of the zinc source.
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Registered trials
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