SynthesisBrain and behavior2019
CACNA1C (rs1006737) may be a susceptibility gene for schizophrenia: An updated meta-analysis.
Synthesis in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- The genome-wide supported CACNA1C gene polymorphisms and the risk of schizophrenia: an updated meta-analysis.BMC medical genetics · 2020Pooled it
- Decreased Risk in the Pancreatic Cancer With History of Hay Fever: A Meta-Analysis.Frontiers in public health · 2020Pooled it
- Dissecting the Epigenetic Changes Induced by Non-Antipsychotic Mood Stabilizers on Schizophrenia and Affective Disorders: A Systematic Review.Frontiers in pharmacology · 2020Pooled it
- CACNA1C (rs1006737) may be a susceptibility gene for schizophrenia: An updated meta-analysis.Brain and behavior · 2019Pooled it
- Deletion ofFrontiers in cellular neuroscience · 2026Article
- Deletion ofbioRxiv : the preprint server for biology · 2025Article
- Calcium Ions in the Physiology and Pathology of the Central Nervous System.International journal of molecular sciences · 2024Review
- Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes.Journal of personalized medicine · 2024Article
- Human-Induced Pluripotent Stem Cell (iPSC)-Derived GABAergic Neuron Differentiation in Bipolar Disorder.Cells · 2024Article
- NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.Brain structure & function · 2024Article
- A Review of theDiseases (Basel, Switzerland) · 2024Review
- Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort.Molecular neurobiology · 2023Article
- CACNA1C-Related Channelopathies.Handbook of experimental pharmacology · 2023Review
- Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia.Current topics in behavioral neurosciences · 2023Review
- Analysis ofGenes · 2022Article
- CACNA1C Gene rs1006737 Polymorphism Affects Cognitive Performance in Chinese Han Schizophrenia.Neuropsychiatric disease and treatment · 2022Article
- Working memory deficits in children with schizophrenia and its mechanism, susceptibility genes, and improvement: A literature review.Frontiers in psychiatry · 2022Review
- Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk.Frontiers in oncology · 2021Article
- Transcriptome analysis of neural progenitor cells derived from Lowe syndrome induced pluripotent stem cells: identification of candidate genes for the neurodevelopmental and eye manifestations.Journal of neurodevelopmental disorders · 2020Article
- DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits.Genome biology · 2019Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSchizophrenia is a serious mental illness with a genetic predisposition. Genome-wide association studies (GWAS) have identified the α-1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene as a significant risk gene for schizophrenia. However, there are inconsistent conclusions in case-control studies.
methodsWe performed a comprehensive meta-analysis of all available samples from existing studies under four different genetic models (recessive model, dominant model, additive model and allele model) to further confirm whether CACNA1C rs1006737 is an authentic risk single nucleotide polymorphism (SNP) for schizophrenia.
resultsA statistically significant difference under the four models (all p < 0.05) was observed by pooling nine Asian and European studies, including a total of 12,744 cases and 16,460 controls. For European-decent samples, a significant difference was identified between patients and controls for the four models (all p < 0.05). We observed a significant difference between patients and controls for the recessive model and allele model (GG vs. GA + AA: p < 0.00001; G vs. A: p < 0.00001) using a fixed effect model, but the dominant model (GG + GA vs. AA: OR: p = 0.15) and additive model (GG vs. AA: p = 0.11) showed no significant difference between patients and controls in the Asian samples.
conclusionOur findings provide important evidence for the establishment of CACNA1C as a susceptibility gene for schizophrenia across world populations, but its roles in the pathogenesis of schizophrenia need to be further investigated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.