Evidence map›Paper›PMID 31033207›Full record

ArticleMicrobiologyOpen2019

Identification of Asparagopsis armata-associated bacteria and characterization of their bioactive potential.

André Horta, Celso Alves, Susete Pinteus, Cláudia Lopes, Nádia Fino, Joana Silva, Joana Ribeiro, Daniel Rodrigues, João Francisco, Américo Rodrigues and 1 more

Open access · goldAbstract read
In one paragraph

Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

André HortaMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.ORCID 0000-0003-2178-1849
Celso AlvesMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.ORCID 0000-0003-1581-2127
Susete PinteusMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.ORCID 0000-0002-3290-3111
Cláudia LopesMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.
Nádia FinoMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.
Joana SilvaMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.ORCID 0000-0003-1224-1699
Joana RibeiroMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.
Daniel RodriguesMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.
João FranciscoMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.
Américo RodriguesMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.ORCID 0000-0002-5293-5583
Rui PedrosaMARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic Institute of Leiria, Peniche, Portugal.ORCID 0000-0003-0970-0575
Instituto Politécnico de Leiria · PT

Funding

Targeted Oncolytic VSV as a Prostate Cancer TherapyR41CA103255 · NCI · GTX, INC. · PI WHITT, MICHAEL A · 2003 to 2003
$131k
Innovative technology for in vitro evolution of proteinsR43CA096203 · NCI · AMBION, INC. · PI CHEN, LIANGJING · 2002 to 2002
$107k
6 · The paper itself

Abstract

Macroalgae-associated bacteria have already proved to be an interesting source of compounds with therapeutic potential. Accordingly, the main aim of this study was to characterize Asparagopsis armata-associated bacteria community and evaluate their capacity to produce substances with antitumor and antimicrobial potential. Bacteria were selected according to their phenotype and isolated by the streak plate technique. The identification was carried out by the RNA ribosomal 16s gene amplification through PCR techniques. The antimicrobial activities were evaluated against seven microorganisms (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Salmonella enteritidis, Staphylococcus aureus, Saccharomyces cerevisiae, Candida albicans) by following their growth through spectrophotometric readings. Antitumor activities were evaluated in vitro on human cell lines derived from hepatocellular (HepG-2) and breast carcinoma (MCF-7) using the MTT method. The present work identified a total of 21 bacteria belonging to the genus Vibrio, Staphylococcus, Shewanella, Alteromonadaceae, Bacillus, Cobetia, and Photobacterium, with Vibrio being the most abundant (42.86%). The extract of Shewanella sp. ASP 26 bacterial strain induced the highest antimicrobial activity, namely against Bacillus subtilis and Staphylococcus aureus with an IC

Indexed as

BiotaAnti-Bacterial AgentsAntineoplastic AgentsBacteriaBacterial Typing TechniquesBiological ProductsCell Line, TumorCell SurvivalCluster AnalysisDNA, BacterialDNA, RibosomalHumansMicrobial Sensitivity TestsPhylogenyRhodophytaRNA, Ribosomal, 16SAnti-Bacterial AgentsAntineoplastic AgentsBiological ProductsDNA, BacterialDNA, RibosomalRNA, Ribosomal, 16SAlgaeAntimicrobialAntitumorEpiphytic bacteriaMarine compoundsMarine symbiosis

Identifiers

PMID31033207
PMCPMC6854849
OpenAlexW2943344922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.