ArticleJournal of biomedical materials research. Part A2019
The improvement of cell infiltration in an electrospun scaffold with multiple synthetic biodegradable polymers using sacrificial PEO microparticles.
Article in Journal of biomedical materials research. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Melt Electrospinning of Poly(ε-caprolactone)/Poly(ethylene oxide)/Poly(ethylene glycol) Blend: Effects on Structure and Cellular Compatibility.ACS omega · 2026Article
- Article
- Role of polymeric nanocomposite for tissue engineering applications.RSC advances · 2026Review
- Evaluating and improving biocompatibility of conductive polymers for cardiac tissue engineering.Journal of materials chemistry. B · 2026Review
- Mechanical Properties of Biodegradable Fibers and Fibrous Mats: A Comprehensive Review.Molecules (Basel, Switzerland) · 2025Review
- Screening of electrospun PS/PCL scaffolds for three-dimensional triple negative breast cancer cell culture: impact of solvent, hydrophobicity, and setup orientation.Scientific reports · 2025Article
- Electrospun poly(lactic acid) membranes with defined pore size to enhance cell infiltration.Heliyon · 2024Article
- Electrospun Polycaprolactone Membranes Expanded with Chitosan Granules for Cell Infiltration.Polymers · 2024Article
- Biofabrication of engineered blood vessels for biomedical applications.Science and technology of advanced materials · 2024Review
- Investigation of osteogenesis and angiogenesis in perfusion bioreactors using improved multi-layer PCL-nHA-nZnO electrospun scaffolds.Biotechnology letters · 2023Article
- Influence of Single-Wall Carbon Nanotube Suspension on the Mechanical Properties of Polymeric Films and Electrospun Scaffolds.International journal of molecular sciences · 2023Article
- Fibrin gel enhanced trilayer structure in cell-cultured constructs.Biotechnology and bioengineering · 2023Article
- PCL-based 3D nanofibrous structure with well-designed morphology and enhanced specific surface area for tissue engineering application.Progress in biomaterials · 2023Article
- Macro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications.Drug design, development and therapy · 2023Review
- Review
- Use of Gelatin as a Sacrificial Agent in Combination with Ultrasonication to Improve Cell Infiltration and Osteogenesis of Nanofibrous PCL-nHA Scaffolds for Bone Tissue Engineering.Iranian journal of biotechnology · 2022Article
- Polyethylene Oxide Assisted Fish Collagen-Poly-ε-Caprolactone Nanofiber Membranes by Electrospinning.Nanomaterials (Basel, Switzerland) · 2022Article
- Assessment of electrospun cardiac patches made with sacrificial particles and polyurethane-polycaprolactone blends.Journal of biomedical materials research. Part A · 2021Article
- Electrospun nanofiber scaffold for vascular tissue engineering.Materials science & engineering. C, Materials for biological applications · 2021Review
- Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing.Pharmaceutics · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Electrospinning is a fabrication technique to generate three dimensional scaffolds with a fiber structure that imitates extracellular matrix for tissue engineering constructs. The versatile characteristics of the electrospinning process yields designer scaffolds made of biodegradable polymers or natural proteins with controllable fiber diameters, biodegradation, and mechanical properties. A limitation of conventional electrospun scaffolds is the dense fiber packing with low porosity that leads to poor cell infiltration. Electrospraying sacrificial polyethylene oxide (PEO) microparticles in combination with electrospun scaffolds are a method to increase porosity. We report the effectiveness of electrospraying PEO microparticles to increase porosity of the most commonly used biodegradable polymers: polyglycolic acid (PGA), poly (lactic-co-glycolic) acid (PLGA), and polycaprolactone (PCL). The biodegradable polymer electrospun scaffolds with the sacrificial PEO microparticles were found to have improved cell proliferation and infiltration with human fibroblasts compared to conventional electrospun scaffolds. The mechanical properties of the more robust PGA and PLGA had minor changes, but the more elastic PCL was observed to be weaker and less stiff after the removal of the PEO microparticles. Therefore, this study found PEO microparticles can increase porosity and cell infiltration with stable mechanical properties for a wide variety of biodegradable polymers in electrospun scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.