ArticleCell proliferation2019
Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment.
Article in Cell proliferation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Surface-Enhanced Raman Scattering Imaging of Dynamic pH Changes in Lysosomes during Cancer Cell Invasion on a Microfluidic Chip.Chemical & biomedical imaging · 2026Article
- Clinical applications of nanoprobes of high-resolutioniScience · 2025Review
- Review
- Design and Detection of Cyanide Raman Tag pH-Responsive SERS Probes.Biosensors · 2022Article
- Recent Progress of SERS Nanoprobe for pH Detecting and Its Application in Biological Imaging.Biosensors · 2021Review
- Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment.Cell proliferation · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesEarly diagnosis of tumour cells is critically important for cancer treatment. Given that the tumour environment is slightly acidic, the pH value of the cell environment can be used as a criterion for tumour diagnosis. However, mapping pH in the cell environment with high resolution, high sensitivity and accuracy remains challenging. MATERIALS AND
methodsBased on gold nanoflower as surface-enhanced Raman scattering (SERS) substrate loading with p-mercaptobenzoic acid (MPA) as pH-responsive Raman reporter, a new SERS nanoprobe for pH mapping was developed.
resultsThis probe showed a characteristic Raman spectrum signal in response to the different pH in solutions or cells. The signal intensity is positively correlated to the pH value. Moreover, this probe is self-correctable, which can help eliminate the influence of probe concentration on the accuracy of pH measuring.
conclusionsWe demonstrate the pH mapping of cell environment using the probe, which can be used to distinguish normal cells and tumour cells. This method may provide a new imaging tool for early diagnosis of cancer.
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Registered trials
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